基于微机电系统的双轴共聚焦显微内镜检查
MEMS-Based Dual Axes Confocal Microendoscopy.
作者信息
Piyawattanametha Wibool, Wang Thomas D
机构信息
National Electronics and Computer Technology Center, Pathumthani 12120, Thailand; Departments of Applied Physics, Biology, Electrical Engineering, Microbiology & Immunology, and Pediatrics, Stanford University, CA 94305 USA (
出版信息
IEEE J Sel Top Quantum Electron. 2010 Jul;16(4):804-814. doi: 10.1109/JSTQE.2009.2032785.
Abstract
We demonstrate a miniature, near-infrared microscope (λ = 785 nm) that uses a novel dual axes confocal architecture. Scalability is achieved with post-objective scanning, and a MEMS mirror provides real time (>4 Hz) in vivo imaging. This instrument can achieve sub-cellular resolution with deep tissue penetration and large field of view. An endoscope-compatible version can image digestive tract epithelium to guide tissue biopsy and monitor therapy.
摘要
我们展示了一种使用新型双轴共焦结构的微型近红外显微镜（波长λ = 785纳米）。通过物镜后扫描实现了可扩展性，并且一个微机电系统（MEMS）镜提供实时（>4赫兹）体内成像。该仪器能够在具有深部组织穿透能力和大视野的情况下实现亚细胞分辨率。一种与内窥镜兼容的版本能够对消化道上皮进行成像，以指导组织活检并监测治疗。
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