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[幼鼠节段性传入神经刺激期间的晚期延长运动放电:左旋多巴的作用]

[The late prolonged motor discharges during stimulation of the segmentary afferents in rat pups: the effect of L-DOPA].

作者信息

Kuznetsov S V, Bursian A V

出版信息

Zh Evol Biokhim Fiziol. 1990 May-Jun;26(3):369-75.

PMID:2220206
Abstract

In experiments on 5-30-day rat puppies, under slight urethane narcosis, studies have been made on the late prolonged discharges in extensor muscles evoked by stimulation of contralateral tibial nerve before and after injection of DOPA. Within the first 16 days, the drug completely abolished or significantly reduced late discharges, increasing the spontaneous motor activity. Beginning from the 16th day, periods of potentiation of late discharges were observed. The data obtained are discussed in relation to the development of mechanisms of control of the activity of spinal generators which are responsible for late discharges and spontaneous motor activity.

摘要

在对5至30日龄幼犬进行的实验中,在轻度氨基甲酸乙酯麻醉下,研究了在注射多巴前后,刺激对侧胫神经诱发的伸肌晚期延长放电。在最初的16天内,该药物完全消除或显著减少了晚期放电,增加了自发运动活动。从第16天开始,观察到晚期放电增强的时期。结合负责晚期放电和自发运动活动的脊髓发生器活动控制机制的发展,对所获得的数据进行了讨论。

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