Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Molecules. 2011 Dec 28;17(1):248-66. doi: 10.3390/molecules17010248.
Evidence shows that honey improves glycemic control in diabetes mellitus. Besides its hypoglycemic effect, studies indicate that honey ameliorates lipid abnormalities in rats and humans with diabetes. The majority of these studies do not examine the mechanisms by which honey ameliorates glycemic and/or lipid derangements. The gut microbiota is now recognized for its ability to increase energy harvest from the diet and alter lipid metabolism of the host. Recently available data implicate a causal role of these gut microbes in the pathophysiology of obesity, insulin resistance, and diabetes mellitus. In this review, we present some of the latest findings linking gut microbiota to pathogenesis of obesity, insulin resistance, and diabetes mellitus. The review also underlines data that demonstrate the beneficial effects of oligosaccharides on various abnormalities commonly associated with these disorders. Based on the similarities of some of these findings with those of honey, together with the evidence that honey contains oligosaccharides, we hypothesize that oligosaccharides present in honey might contribute to the antidiabetic and other health-related beneficial effects of honey. We anticipate that the possibility of oligosaccharides in honey contributing to the antidiabetic and other health-related effects of honey will stimulate a renewed research interest in this field.
证据表明，蜂蜜可改善糖尿病患者的血糖控制。除了降血糖作用外，研究还表明，蜂蜜可改善糖尿病大鼠和人类的脂质异常。这些研究大多数都没有研究蜂蜜改善血糖和/或脂质紊乱的机制。肠道微生物群现在因其能够增加从饮食中获取能量并改变宿主脂质代谢的能力而受到关注。最近的数据表明，这些肠道微生物在肥胖、胰岛素抵抗和糖尿病的病理生理学中起因果作用。在这篇综述中，我们介绍了一些将肠道微生物群与肥胖、胰岛素抵抗和糖尿病发病机制联系起来的最新发现。该综述还强调了一些数据，这些数据表明低聚糖对与这些疾病相关的各种异常具有有益的影响。基于这些发现与蜂蜜的某些发现相似，并且蜂蜜中含有低聚糖，我们假设蜂蜜中存在的低聚糖可能有助于蜂蜜的抗糖尿病和其他与健康相关的有益作用。我们预计，蜂蜜中的低聚糖可能有助于蜂蜜的抗糖尿病和其他与健康相关的作用，这将激发人们对该领域的新的研究兴趣。
