MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, UK.
J Child Psychol Psychiatry. 2012 Jul;53(7):757-66. doi: 10.1111/j.1469-7610.2011.02518.x. Epub 2011 Dec 29.
Depression in adolescence is common and early onset predicts worse outcome in adulthood. Studies in adults have suggested a link between higher total 25-hydroxyvitamin D [25(OH)D] concentrations and lower risk of depression.
To investigate (a) the association between serum 25(OH)D(2) and 25(OH)D(3) concentrations and depressive symptoms in children, and (b) whether the associations of 25(OH)D(2) and 25(OH)D(3) are different from, and independent of, each other.
Prospective cohort study with serum 25(OH)D(2) and 25(OH)D(3) concentrations measured at mean age of 9.8 years and depressive symptoms assessed with the Mood and Feelings Questionnaire by a trained interviewer at the mean ages of 10.6 years (n = 2,759) and 13.8 years (n = 2,752).
Higher concentrations of 25(OH)D(3) assessed at mean age 9.8 years were associated with lower levels of depressive symptoms at age 13.8 years [adjusted risk ratio (RR; 95% confidence interval (CI)): 0.90 (0.86-0.95)], but not at age 10.6 years [adjusted RR (95% CI): 0.98 (0.93-1.03)] and with increased odds of decreasing symptoms between age 10.6 and 13.8 years [adjusted RR (95% CI): 1.08 (1.01-1.16)]. Serum 25(OH)D(2) concentrations were not associated with depressive symptoms.
This is the first study in children to suggest that the association between 25(OH)D(3) concentrations and depression emerges in childhood. The association is independent of a wide range of potential confounding factors, and appears to be stronger with greater time separation between assessment of 25(OH)D(3) and assessment of depressive symptoms. Confirmation of our findings in large prospective studies and trials would be valuable.
青春期抑郁症很常见，发病年龄早预示着成年后患抑郁症的风险更高。成年人的研究表明，总 25-羟维生素 D [25(OH)D] 浓度较高与患抑郁症的风险较低之间存在关联。
研究（a）儿童血清 25(OH)D(2)和 25(OH)D(3)浓度与抑郁症状之间的关系，以及（b）25(OH)D(2)和 25(OH)D(3)的关联是否与彼此不同且独立。
这是一项前瞻性队列研究，在儿童平均年龄为 9.8 岁时测量血清 25(OH)D(2)和 25(OH)D(3)浓度，在平均年龄为 10.6 岁（n=2759）和 13.8 岁（n=2752）时由经过培训的访谈者使用情绪和情感问卷评估抑郁症状。
在平均年龄 9.8 岁时，较高的 25(OH)D(3)浓度与 13.8 岁时的抑郁症状水平较低相关[调整风险比（RR；95%置信区间（CI））：0.90（0.86-0.95)]，但与 10.6 岁时无关[调整 RR（95%CI）：0.98（0.93-1.03)]，与 10.6 岁至 13.8 岁期间症状减轻的可能性增加相关[调整 RR（95%CI）：1.08（1.01-1.16)]。血清 25(OH)D(2)浓度与抑郁症状无关。
这是第一项在儿童中进行的研究，表明 25(OH)D(3)浓度与抑郁症之间的关联在儿童期就出现了。该关联独立于广泛的潜在混杂因素，并且随着评估 25(OH)D(3)和评估抑郁症状之间的时间间隔增大而变得更强。在大型前瞻性研究和试验中确认我们的研究结果将具有重要价值。
