菲律宾艾滋病毒感染者的血液学特征及其与CD4细胞计数的关联。

The hematologic profile of Filipino HIV-infected individuals and its association with CD4 counts.

作者信息

Vaswani Preeti Prerna M, Senga-Tang Issa Rufina, Catapia Jean Rachel M, Abad Cybele Lara R, Dumagay Teresita E

机构信息

Division of Hematology, Department of Medicine, University of the Philippines, Philippine General Hospital, Manila, Philippines.

Division of Infectious Diseases, Department of Medicine, University of the Philippines, Philippine General Hospital, Manila, Philippines.

出版信息

Hematol Transfus Cell Ther. 2022 Jul-Sep;44(3):307-313. doi: 10.1016/j.htct.2020.10.964. Epub 2021 Jan 3.

DOI:10.1016/j.htct.2020.10.964

PMID:33431267

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9477755/

Abstract

INTRODUCTION

Hematologic abnormalities are common in HIV and involve all blood cell lineages. A study on cytopenias, as correlated with disease progression, can be valuable in resource-limited settings. This study aimed to determine the hematologic profile of HIV patients and its association with CD4 count and antiretroviral (ARV) treatment.

METHODS

This is a retrospective cohort study involving adult Filipino HIV patients with complete blood count (CBC) and CD4 count determinations prior to the initiation of ARV treatment and after ≥6 months of ARV treatment. Logistic regression was performed to determine the association between cytopenias and a CD4 count <200 cells/µL.

RESULTS

The study included 302 patients. Anemia was the most common cytopenia. Anemia and leukopenia were associated with an increased likelihood of having a CD4 count <200 cells/µL in ARV-naïve patients. In ARV-treated patients, leukopenia was associated with an increased probability of having a CD4 count <200 cells/µL. An increase in hemoglobin, white blood cell (WBC) and platelet counts was observed after ≥6 months of ARV treatment.

CONCLUSION

Anemia and leukopenia can be used as markers of immune status in HIV-infected individuals and improvement in the CBC parameters can be used to assess response to ARV treatment. Routine monitoring of hematologic parameters is recommended.

摘要

引言

血液学异常在HIV患者中很常见，涉及所有血细胞谱系。在资源有限的环境中，一项关于血细胞减少症与疾病进展相关性的研究可能很有价值。本研究旨在确定HIV患者的血液学特征及其与CD4细胞计数和抗逆转录病毒（ARV）治疗的关联。

方法

这是一项回顾性队列研究，纳入了成年菲律宾HIV患者，这些患者在开始ARV治疗前和ARV治疗≥6个月后进行了全血细胞计数（CBC）和CD4细胞计数测定。进行逻辑回归以确定血细胞减少症与CD4细胞计数<200个/µL之间的关联。

结果

该研究纳入了302名患者。贫血是最常见的血细胞减少症。在未接受ARV治疗的患者中，贫血和白细胞减少与CD4细胞计数<200个/µL的可能性增加有关。在接受ARV治疗的患者中，白细胞减少与CD4细胞计数<200个/µL的可能性增加有关。ARV治疗≥6个月后，血红蛋白、白细胞（WBC）和血小板计数有所增加。