Laboratório de Fitoquímica e Síntese Orgânica, Departamento de Produção de Matéria-Prima, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre, Rio Grande do Sul, Brazil.
Parasitol Res. 2012 Jun;110(6):2551-6. doi: 10.1007/s00436-011-2798-1. Epub 2012 Jan 5.
Trichomonas vaginalis is a flagellated protozoan that causes trichomonosis, the most prevalent non-viral STD worldwide. The pathogen has been associated with serious health consequences including predisposition to cervical cancer and adverse pregnancy outcomes and infertility. It also acts as a co-factor in HIV transmission and acquisition. The 5-nitroimidazole drugs are used in the treatment, however, treatment noncompliance is observed, and a growing number of T. vaginalis isolates resistant to the drugs have been related. Saponins are natural products possessing many biological activities such as antiprotozoan activity. The aim of this study was to evaluate the anti-T. vaginalis activity of saponins from Quillaja, Passiflora, and Ilex species. Saponins from Passiflora alata and Quillaja saponaria presented the best anti-T. vaginalis activity (MIC = 0.025%). In addition, all samples induced erythrocyte lysis and LDH release. As far as we know, this is the first report demonstrating the potential anti-T. vaginalis activity of these saponins.
阴道毛滴虫是一种鞭毛原生动物，可引起滴虫病，这是全球最常见的非病毒性性传播疾病。该病原体与包括宫颈癌易感性、不良妊娠结局和不孕在内的严重健康后果有关。它也是 HIV 传播和获得的协同因素。5-硝基咪唑类药物用于治疗，但观察到治疗不依从性，并且与越来越多的对药物耐药的阴道毛滴虫分离株有关。皂苷是具有多种生物活性的天然产物，如抗原生动物活性。本研究旨在评估 Quillaja、Passiflora 和 Ilex 物种中的皂苷抗阴道毛滴虫活性。Passiflora alata 和 Quillaja saponaria 的皂苷表现出最好的抗阴道毛滴虫活性（MIC = 0.025%）。此外，所有样品均诱导红细胞溶解和 LDH 释放。据我们所知，这是首次报道这些皂苷具有抗阴道毛滴虫活性的潜力。
