Department of Surgery, Emory Transplant Center, Emory University School of Medicine, Atlanta, GA, USA.
Am J Transplant. 2012 Feb;12(2):369-78. doi: 10.1111/j.1600-6143.2011.03888.x. Epub 2012 Jan 6.
Racial disparities persist in access to renal transplantation in the United States, but the degree to which patient and neighborhood socioeconomic status (SES) impacts racial disparities in deceased donor renal transplantation access has not been examined in the pediatric and adolescent end-stage renal disease (ESRD) population. We examined the interplay of race and SES in a population-based cohort of all incident pediatric ESRD patients <21 years from the United States Renal Data System from 2000 to 2008, followed through September 2009. Of 8452 patients included, 30.8% were black, 27.6% white-Hispanic, 44.3% female and 28.0% lived in poor neighborhoods. A total of 63.4% of the study population was placed on the waiting list and 32.5% received a deceased donor transplant. Racial disparities persisted in transplant even after adjustment for SES, where minorities were less likely to receive a transplant compared to whites, and this disparity was more pronounced among patients 18-20 years. Disparities in access to the waiting list were mitigated in Hispanic patients with private health insurance. Our study suggests that racial disparities in transplant access worsen as pediatric patients transition into young adulthood, and that SES does not explain all of the racial differences in access to kidney transplantation.
在美国,接受肾移植的机会存在种族差异,但患者和社区社会经济地位(SES)对接受已故供体肾移植机会的种族差异的影响程度,尚未在儿科和青少年终末期肾病(ESRD)患者中进行研究。我们在美国肾脏数据系统中研究了 2000 年至 2008 年期间所有年龄在 21 岁以下的新发病例儿科 ESRD 患者的人群队列中种族和 SES 的相互作用,随访至 2009 年 9 月。在 8452 名患者中,30.8%为黑人,27.6%为白西班牙裔,44.3%为女性,28.0%生活在贫困社区。研究人群中有 63.4%的患者被列入等候名单,32.5%接受了已故供体移植。即使在调整 SES 后,移植中仍然存在种族差异,少数民族患者接受移植的可能性低于白人患者,而这种差异在 18-20 岁的患者中更为明显。具有私人医疗保险的西班牙裔患者在获得等候名单方面的差异有所缓解。我们的研究表明,随着儿科患者进入成年早期,移植机会的种族差异加剧,而 SES 并不能解释所有在获得肾移植方面的种族差异。