Afolayan Michael, Srivedavyasasri Radhakrishnan, Asekun Olayinka T, Familoni Oluwole B, Ross Samir A
a National Center for Natural Product Research , University of Mississippi , University , MS , USA.
b Department of Chemistry , University of Lagos , Lagos , Nigeria.
Nat Prod Res. 2019 Jan;33(2):287-291. doi: 10.1080/14786419.2018.1440225. Epub 2018 Feb 19.
Phytochemical investigation of the methanolic extract of dried leaves of Bridelia ferruginea led to the isolation and identification of fourteen compounds (1-14): compound 1 [mixture of palmitic, stearic and oleic acids], stearyl monoester of 2-O-β-ᴅ-glucosylglycerol (2), 6β-hydroxy-(20R)-24-ethylcholest-4-en-3-one (3a), 6β-hydroxy-(20R)-24-ethylcholest-4,22-dien-3-one (3b), lutein (4), vomifoliol (5), corilagin (6), kaempferide-3-O-β-ᴅ-glucoside (7), myricetin (8), isomericitrin (9), isoquercetin (10), myricitrin (11), quercitrin (12), rutin (13), and β-sitosterol glucoside (14). The total extract exhibited moderate activity towards CB2 receptor and 90% inhibition against leishmanial pathogen Trypanosoma brucei. Compound 4 exhibited 73% displacement in CB2 receptor with IC 56.47 μM, and 93% inhibition towards T. brucei with IC 4.16 μM. Compound 11 showed 99% inhibition towards Escherichia coli with IC 1.123 μM.
对锈毛算盘子干燥叶的甲醇提取物进行植物化学研究，分离并鉴定出14种化合物（1 - 14）：化合物1 [棕榈酸、硬脂酸和油酸的混合物]、2 - O-β -ᴅ-葡萄糖基甘油硬脂单酯（2）、6β - 羟基 - (20R)-24 - 乙基胆甾 - 4 - 烯 - 3 - 酮（3a）、6β - 羟基 - (20R)-24 - 乙基胆甾 - 4,22 - 二烯 - 3 - 酮（3b）、叶黄素（4）、vomifoliol（5）、柯里拉京（6）、山柰酚 - 3 - O-β -ᴅ-葡萄糖苷（7）、杨梅素（8）、异鼠李素（9）、异槲皮苷（10）、杨梅苷（11）、槲皮苷（12）、芦丁（13）和β - 谷甾醇葡萄糖苷（14）。总提取物对CB2受体表现出中等活性，对利什曼原虫病原体布氏锥虫有90%的抑制作用。化合物4在CB2受体中的取代率为73%，IC56.47 μM，对布氏锥虫的抑制率为93%，IC4.16 μM。化合物11对大肠杆菌的抑制率为99%，IC1.123 μM。
