Mahomoodally Mohamad Fawzi, Jugreet Sharmeen, Sinan Kouadio Ibrahime, Zengin Gokhan, Ak Gunes, Ceylan Ramazan, Jekő József, Cziáky Zoltán, Angelini Paola, Angeles Flores Giancarlo, Venanzoni Roberto, Di Simone Simonetta Cristina, Menghini Luigi, Orlando Giustino, Ferrante Claudio, Etienne Ouattara Katinan, Tacchini Massimo
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City 758307, Vietnam.
Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 758307, Vietnam.
Antibiotics (Basel). 2021 Feb 23;10(2):223. doi: 10.3390/antibiotics10020223.
To avail the possible pharmacological actions of Benth., the present investigation was designed to quantitatively analyze the total flavonoid and phenolic contents and assess the various antioxidant and enzyme inhibition properties of leaf and stem bark extracts (ethyl acetate, water and methanolic) of Anti-proliferative effect was also investigated against human colon cancer cells (HCT116) as well as the antimicrobial potential against multiple bacterial and fungal (yeasts and dermatophytes) strains. The methanolic and water extracts of the stem bark demonstrated the highest phenolic content (193.58 ± 0.98 and 187.84 ± 1.88 mg/g, respectively), while the leaf extracts showed comparatively higher flavonoid contents (24.37-42.31 mg/g). Overall, the methanolic extracts were found to possess the most significant antioxidant potency. Compared to the other extracts, methanolic extracts of the were revealed to be most potent inhibitors of acetyl- and butyryl-cholinesterases, tyrosinase -amylase, except -glucosidase. Only the ethyl acetate extracts were found to inhibit glucosidase. Additionally, the stem bark methanolic extract also showed potent inhibitory activity against and gram-positive bacteria (MIC (minimum inhibitory concentration): 2.48-62.99 µg/mL), as well as all the tested fungi (MIC: 4.96-62.99 µg/mL). In conclusion, can be regarded as a promising source of bioactive compounds displaying multifunctional pharmacological activities and thus is a potential candidate for further investigations in the endeavor to develop botanical formulations for pharmaceutical and cosmeceutical industries.
为了利用[植物名称]的潜在药理作用，本研究旨在定量分析总黄酮和酚类含量，并评估叶和茎皮提取物（乙酸乙酯、水和甲醇提取物）的各种抗氧化和酶抑制特性。还研究了其对人结肠癌细胞（HCT116）的抗增殖作用以及对多种细菌和真菌（酵母和皮肤癣菌）菌株的抗菌潜力。茎皮的甲醇提取物和水提取物显示出最高的酚类含量（分别为193.58±0.98和187.84±1.88 mg/g），而叶提取物的黄酮含量相对较高（24.37 - 42.31 mg/g）。总体而言，发现甲醇提取物具有最显著的抗氧化能力。与其他提取物相比，[植物名称]的甲醇提取物被发现是乙酰胆碱酯酶和丁酰胆碱酯酶、酪氨酸酶、淀粉酶（除了α - 葡萄糖苷酶）的最有效抑制剂。仅发现乙酸乙酯提取物能抑制葡萄糖苷酶。此外，茎皮甲醇提取物对革兰氏阴性菌和革兰氏阳性菌也显示出强效抑制活性（最低抑菌浓度（MIC）：2.48 - 62.99 µg/mL），以及对所有测试的真菌（MIC：4.96 - 62.99 µg/mL）。总之，[植物名称]可被视为一种有前景的生物活性化合物来源，具有多功能药理活性，因此是进一步研究开发用于制药和化妆品行业植物制剂的潜在候选物。
