Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Cornea. 2012 Apr;31(4):418-23. doi: 10.1097/ICO.0b013e31823f098c.
To evaluate the repeatability of Fourier domain optical coherence tomography (OCT) pachymetric mapping in patients with corneal opacities and to assess the reliability of Fourier domain OCT with 830 nm wavelength as a pachymetric measurement tool in opaque corneas.
A Fourier domain OCT system was used to map the corneal thickness of patients with corneal scars or dystrophy. A retrospective study of a consecutive series was conducted. The repeatability was measured using pooled standard deviation of repeated measurements. A slit-scanning tomography device provided pachymetric mapping for comparison.
Seventeen eyes of 12 patients with corneal scars (7 trauma and 3 post infection) or dystrophy (2 Reis-Bucklers and 5 granular dystrophy) were included. The posterior corneal boundary was detectable in all cases. The average corneal thickness measured by OCT was 536 ± 89 μm in central 2 mm area, 553 ± 76 μm in pericentral 2- to 5-mm area, and 508 ± 93 μm for the minimum corneal thickness. The slit-scanning tomography central corneal thickness, 433 ± 111 μm, was significantly lower than OCT readings (mean difference -91.1 ± 33.3 μm, P = 0.002). Repeatability of the OCT measurements was 2.1 μm centrally and 1.2 μm pericentrally.
Pachymetric mapping with Fourier domain OCT was highly repeatable. Fourier domain OCT is a reliable pachymetric tool in opaque corneas. In comparison, corneal thickness measured by the slit-scanning tomography is significantly thinner than those measured by the Fourier domain OCT in the presence of corneal opacities.
评估傅里叶域光学相干断层扫描（OCT）在角膜混浊患者中的角膜厚度重复性，并评估 830nm 波长傅里叶域 OCT 作为混浊角膜的角膜厚度测量工具的可靠性。
使用傅里叶域 OCT 系统对角膜瘢痕或营养不良患者的角膜厚度进行测绘。进行了一项连续系列的回顾性研究。使用重复测量的 pooled 标准差来测量重复性。使用裂隙扫描层析成像设备提供角膜厚度测绘进行比较。
纳入了 12 例角膜瘢痕（7 例创伤和 3 例感染后）或营养不良（2 例 Reis-Bucklers 和 5 例颗粒状营养不良）患者的 17 只眼。所有病例均能检测到后角膜边界。OCT 测量的平均角膜中央厚度为 2mm 区域内 536±89μm，中央至周边 2-5mm 区域内 553±76μm，最小角膜厚度为 508±93μm。裂隙扫描层析成像的角膜中央厚度为 433±111μm，明显低于 OCT 读数（平均差值-91.1±33.3μm，P=0.002）。OCT 测量的重复性为中央 2.1μm 和周边 1.2μm。
傅里叶域 OCT 的角膜厚度测绘重复性高。傅里叶域 OCT 是混浊角膜的可靠角膜厚度测量工具。相比之下，在存在角膜混浊的情况下，裂隙扫描层析成像测量的角膜厚度明显比傅里叶域 OCT 测量的薄。
