Hernández-Muñoz R, Montiel-Ruíz F
Departamento de Bioenergética, Universidad Nacional Autónoma de México, D.F., Mexico.
Dig Dis Sci. 1996 Nov;41(11):2156-65. doi: 10.1007/BF02071395.
Ethanol administration rapidly damages surface epithelial cells of rat stomach, leading to altered cellular plasma membranes. Histamine H2-receptor antagonists (H2RA) have been shown to have preventive properties against ethanol-induced gastric mucosal injury. Therefore, the possible reverting properties of H2RA (cimetidine, ranitidine, and famotidine) were tested in ethanol-induced gastritis. Subchronic ethanol administration elicited a histological profile of gastritis and alterations at the plasma membrane level (diminution of some phospholipids, increased cholesterol, and decreased activity of 5'-nucleotidase). H2RA administration to rats with gastritis promptly corrected the ethanol-induced mucosal damage. In addition, cytosolic enzyme activities (alcohol and lactate dehydrogenases) were also modified by gastritis and treatment with H2RA. In conclusion, our data suggest that H2RA improved restitution of the gastric mucosa contributing to the healing process of the gastric damage. The latter indicates reverting properties of H2RA on gastric damage, as well as their cytoprotective effect already described.
给予乙醇会迅速损伤大鼠胃的表面上皮细胞，导致细胞膜发生改变。组胺H2受体拮抗剂（H2RA）已被证明对乙醇诱导的胃黏膜损伤具有预防作用。因此，在乙醇诱导的胃炎中测试了H2RA（西咪替丁、雷尼替丁和法莫替丁）可能的恢复特性。亚慢性给予乙醇引发了胃炎的组织学特征以及细胞膜水平的改变（某些磷脂减少、胆固醇增加和5'-核苷酸酶活性降低）。给患有胃炎的大鼠施用H2RA可迅速纠正乙醇诱导的黏膜损伤。此外，细胞溶质酶活性（乙醇脱氢酶和乳酸脱氢酶）也因胃炎和H2RA治疗而发生改变。总之，我们的数据表明H2RA促进了胃黏膜的恢复，有助于胃损伤的愈合过程。后者表明H2RA对胃损伤具有恢复特性，以及它们已被描述的细胞保护作用。
