Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Virol J. 2012 Jan 13;9:16. doi: 10.1186/1743-422X-9-16.
Persistent hepatitis B virus (HBV) infection is a risk factor for hepatocellular carcinoma (HCC) development. This study aimed to clarify whether the high HBV DNA level is associated with HCC development by comparing HBV DNA levels between HBV infected patients with and without HCC.
There were 78 male and 12 female patients in each group and there was no statistical difference between these two group patients' average ages. The HBV DNA level in the HCC patients was 4.73 ± 1.71 Log10 IU/ml while 3.90 ± 2.01 Log10 IU/ml in non-HCC patients (P < 0.01). The HBeAg positive rate was 42.2% (38/90) in the HCC group while 13.3% (12/90) in the non-HCC group (P < 0.001). Compared with patients with HBV DNA level of < 3 Log10 IU/ml, the patients with level of 3 to < 4, 4 to < 5, 5 to < 6, or ≥ 6 Log10 IU/ml had the odds ratio for HCC of 1.380 (95% CI, 0.544-3.499), 3.671 (95% CI, 1.363-9.886), 5.303 (95% CI, 1.847-15.277) or 3.030 (95% CI, 1.143-8.036), respectively.
HBV-related HCC patients had higher HBV DNA level than non-HCC counterparts. Our findings imply that active HBV replication is associated with the HCC development.
持续性乙型肝炎病毒（HBV）感染是肝细胞癌（HCC）发展的一个危险因素。本研究旨在通过比较 HBV 感染患者中 HCC 和非 HCC 患者的 HBV DNA 水平，阐明高 HBV DNA 水平是否与 HCC 发展有关。
两组患者的平均年龄无统计学差异，每组均有 78 名男性和 12 名女性。HCC 患者的 HBV DNA 水平为 4.73 ± 1.71 Log10 IU/ml，而非 HCC 患者为 3.90 ± 2.01 Log10 IU/ml（P < 0.01）。HBeAg 阳性率在 HCC 组为 42.2%（38/90），而非 HCC 组为 13.3%（12/90）（P < 0.001）。与 HBV DNA 水平<3 Log10 IU/ml 的患者相比，HBV DNA 水平为 3 至<4、4 至<5、5 至<6 和≥6 Log10 IU/ml 的患者 HCC 的比值比分别为 1.380（95%CI，0.544-3.499）、3.671（95%CI，1.363-9.886）、5.303（95%CI，1.847-15.277）和 3.030（95%CI，1.143-8.036）。
HBV 相关 HCC 患者的 HBV DNA 水平高于非 HCC 患者。我们的研究结果表明，HBV 复制活跃与 HCC 发展有关。
