在酿酒酵母中，mRNA 折叠强度与蛋白质丰度之间存在很强的关联。
Strong association between mRNA folding strength and protein abundance in S. cerevisiae.
机构信息
School of Computer Science, and Faculty of Engineering, Department of Biomedical Engineering, Tel Aviv University, Ramat Aviv 69978, Israel.
出版信息
EMBO Rep. 2012 Mar 1;13(3):272-7. doi: 10.1038/embor.2011.262.
Abstract
One of the open questions in regulatory genomics is how the efficiency of gene translation is encoded in the coding sequence. Here we analyse recently generated measurements of folding energy in Saccharomyces cerevisiae, showing that genes with high protein abundance tend to have strong mRNA folding (mF; R=0.68). mF strength also strongly correlates with ribosomal density and mRNA levels, suggesting that this relation at least partially pertains to the efficiency of translation elongation, presumably by preventing aggregation of mRNA molecules.
摘要
调控基因组学中的一个开放性问题是基因翻译的效率如何编码在编码序列中。在这里，我们分析了最近在酿酒酵母中产生的折叠能测量结果，结果表明高蛋白质丰度的基因往往具有较强的 mRNA 折叠（mF；R=0.68）。mF 强度也与核糖体密度和 mRNA 水平强烈相关，这表明这种关系至少部分归因于翻译延伸的效率，可能是通过防止 mRNA 分子的聚集。
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