Nutrition and Metabolism Group, Heart Research Institute, 7 Eliza St. Newtown 2042 NSW, Sydney, Australia.
Nutrients. 2010 Feb;2(2):116-27. doi: 10.3390/nu2020116. Epub 2010 Feb 8.
Experiments carried out with cultured cells and in experimental animals have consistently shown that phospholipids (PLs) can inhibit intestinal cholesterol absorption. Limited evidence from clinical studies suggests that dietary PL supplementation has a similar effect in man. A number of biological mechanisms have been proposed in order to explain how PL in the gut lumen is able to affect cholesterol uptake by the gut mucosa. Further research is however required to establish whether the ability of PLs to inhibit cholesterol absorption is of therapeutic benefit.
经细胞培养和动物实验证实，磷脂（PLs）可抑制肠道胆固醇吸收。来自临床研究的有限证据表明，膳食 PL 补充也具有相似的作用。为了解释肠道腔中的 PL 如何影响肠黏膜摄取胆固醇，提出了许多生物学机制。然而，还需要进一步的研究来确定 PL 抑制胆固醇吸收的能力是否具有治疗益处。
