肺癌、甲状腺癌还是两者都有：一个不寻常的病例报告。
Lung cancer, thyroid cancer or both: An unusual case presentation.
机构信息
Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, USA.
出版信息
J Thorac Dis. 2011 Dec;3(4):271-3. doi: 10.3978/j.issn.2072-1439.2011.02.03.
Abstract
Cancer metastasis to the thyroid is rare. Primary sites that have been reported to metastasize to the thyroid gland include breast and kidney. There are very few case reports describing metastasis of a lung primary cancer to the thyroid gland. We describe a case of a never-smoker patient with metastatic adenocarcinoma of the lung and a malignant thyroid mass presenting simultaneously. The thyroid biopsy could not distinguish whether it was a metastasis or incidentally found thyroid primary carcinoma. Based on EGFR mutational status it was determined that he has a primary lung cancer and thyroid metastasis. He was started on erlotinib and has had a marked response in both the lung and the thyroid masses. The presence of mutations within the EGFR gene can help distinguish lung adenocarcinoma from other carcinomas like thyroid cancer. This is the first published case of primary lung adenocarcinoma with metastasis to thyroid and with EGFR mutation.
摘要
癌症转移至甲状腺较为罕见。据报道，有多种原发性肿瘤可转移至甲状腺，包括乳腺和肾脏。仅有少数病例报告描述了原发性肺癌转移至甲状腺。我们描述了一例从未吸烟的患者，其同时患有转移性肺腺癌和甲状腺恶性肿块。甲状腺活检无法区分这是转移灶还是偶然发现的甲状腺原发性癌。根据 EGFR 基因突变状态，确定他患有原发性肺癌和甲状腺转移。他开始接受厄洛替尼治疗，肺部和甲状腺肿块均有明显缓解。EGFR 基因内的突变存在有助于将肺腺癌与其他癌（如甲状腺癌）区分开来。这是首例经 EGFR 基因突变证实的原发性肺腺癌伴甲状腺转移的病例。
相似文献
1
Lung cancer, thyroid cancer or both: An unusual case presentation.肺癌、甲状腺癌还是两者都有：一个不寻常的病例报告。
J Thorac Dis. 2011 Dec;3(4):271-3. doi: 10.3978/j.issn.2072-1439.2011.02.03.
2
Tumor-to-tumor metastasis: lung adenocarcinoma metastasizing to a follicular variant of papillary thyroid carcinoma.肿瘤对肿瘤转移：肺腺癌转移至甲状腺滤泡状乳头状癌的滤泡变体。
Pathol Int. 2011 Jul;61(7):435-41. doi: 10.1111/j.1440-1827.2011.02679.x. Epub 2011 May 23.
3
Intrathyroid metastasis presenting as a solitary thyroid nodule: an unusual case of clinically silent lung cancer.表现为孤立性甲状腺结节的甲状腺内转移：一例罕见的临床隐匿性肺癌病例
Kathmandu Univ Med J (KUMJ). 2008 Jan-Mar;6(1):109-11.
4
Case report: small cell transformation and metastasis to the breast in a patient with lung adenocarcinoma following maintenance treatment with epidermal growth factor receptor tyrosine kinase inhibitors.病例报告：一名肺腺癌患者在接受表皮生长因子受体酪氨酸激酶抑制剂维持治疗后发生小细胞转化并转移至乳腺。
BMC Cancer. 2016 Aug 3;16:593. doi: 10.1186/s12885-016-2623-4.
5
Thyroid gland metastasis from small cell lung cancer: an unusual site of metastatic spread.甲状腺转移来自小细胞肺癌：一种不常见的转移部位。
J Thorac Dis. 2013 Apr;5(2):E21-4. doi: 10.3978/j.issn.2072-1439.2012.06.03.
6
Thyroid metastasis revealing a lung adenocarcinoma: A case report and review of the literature.甲状腺转移瘤揭示肺腺癌：一例病例报告及文献复习
Int J Surg Case Rep. 2022 Sep;98:107525. doi: 10.1016/j.ijscr.2022.107525. Epub 2022 Aug 18.
7
Folliculotropic Cutaneous Metastases and Lymphangitis Carcinomatosa: When Cutaneous Metastases of Breast Carcinoma Are Mistaken for Cutaneous Infections.毛囊性皮肤转移瘤和癌性淋巴管炎：乳腺癌皮肤转移被误诊为皮肤感染时的情况。
Acta Dermatovenerol Croat. 2016 Jun;24(2):154-7.
8
L858R EGFR mutation status correlated with clinico-pathological features of Japanese lung cancer.L858R表皮生长因子受体（EGFR）突变状态与日本肺癌患者的临床病理特征相关。
Lung Cancer. 2006 Oct;54(1):103-8. doi: 10.1016/j.lungcan.2006.06.003. Epub 2006 Aug 4.
9
Isolated thyroid metastasis revealed an unknown lung adenocarcinoma: a case report.孤立性甲状腺转移瘤提示为未知的肺腺癌：一例报告
J Med Case Rep. 2015 Sep 27;9:221. doi: 10.1186/s13256-015-0663-z.
10
Erlotinib response of EGFR-mutant gefitinib-resistant non-small-cell lung cancer.表皮生长因子受体（EGFR）突变的吉非替尼耐药非小细胞肺癌对厄洛替尼的反应
Lung Cancer. 2007 Dec;58(3):414-7. doi: 10.1016/j.lungcan.2007.05.018. Epub 2007 Jul 6.
引用本文的文献
1
The Interplay Between Cardiovascular Disease and Lung Cancer.心血管疾病与肺癌之间的相互作用
Cureus. 2024 Jun 23;16(6):e62953. doi: 10.7759/cureus.62953. eCollection 2024 Jun.
2
Thyroid metastasis revealing a lung adenocarcinoma: A case report and review of the literature.甲状腺转移瘤揭示肺腺癌：一例病例报告及文献复习
Int J Surg Case Rep. 2022 Sep;98:107525. doi: 10.1016/j.ijscr.2022.107525. Epub 2022 Aug 18.
3
Clinicopathological and Molecular Features of Secondary Cancer (Metastasis) to the Thyroid and Advances in Management.甲状腺继发癌（转移）的临床病理和分子特征及治疗进展。
Int J Mol Sci. 2022 Mar 17;23(6):3242. doi: 10.3390/ijms23063242.
4
Thyroid metastasis revealing a lung adenocarcinoma.甲状腺转移瘤提示肺腺癌。
Respir Med Case Rep. 2020 May 16;30:101065. doi: 10.1016/j.rmcr.2020.101065. eCollection 2020.
5
Genomic Profiling Reveals Medullary Thyroid Cancer Misdiagnosed as Lung Cancer.基因组分析揭示了被误诊为肺癌的甲状腺髓样癌。
Case Rep Oncol. 2018 Jun 22;11(2):399-403. doi: 10.1159/000490238. eCollection 2018 May-Aug.
6
Diagnosis and Treatment of Metastases to the Thyroid Gland: a Meta-Analysis.甲状腺转移瘤的诊断与治疗：一项荟萃分析
Endocr Pathol. 2017 Jun;28(2):112-120. doi: 10.1007/s12022-017-9475-6.
7
Real-time tests of multiple genome alterations take the first steps into the clinic: a learning example.多种基因组改变的实时检测首次进入临床：一个学习范例。
Onco Targets Ther. 2016 Aug 30;9:5399-404. doi: 10.2147/OTT.S104748. eCollection 2016.
8
Pitfall in immunohistochemical staining for thyroglobulin in case of thyroid metastasis from lung carcinoma.肺癌甲状腺转移病例中甲状腺球蛋白免疫组化染色的陷阱。
Cytojournal. 2015 Nov 30;12:27. doi: 10.4103/1742-6413.170734. eCollection 2015.
9
Epidermal growth factor mutation as a diagnostic and therapeutic target in metastatic poorly differentiated thyroid carcinoma: a case report and review of the literature.表皮生长因子突变作为转移性低分化甲状腺癌的诊断和治疗靶点：一例病例报告及文献综述
Case Rep Oncol. 2014 Jun 18;7(2):393-400. doi: 10.1159/000364856. eCollection 2014 May.
10
Thyroid metastasis from nonsmall cell lung cancer.非小细胞肺癌的甲状腺转移
Case Rep Oncol Med. 2013;2013:208213. doi: 10.1155/2013/208213. Epub 2013 Dec 19.
本文引用的文献
1
Lung cancer in never smokers: a review.从不吸烟者的肺癌：综述
J Clin Oncol. 2007 Feb 10;25(5):561-70. doi: 10.1200/JCO.2006.06.8015.
2
Current knowledge and future directions of the selective epidermal growth factor receptor inhibitors erlotinib (Tarceva) and gefitinib (Iressa).选择性表皮生长因子受体抑制剂厄洛替尼（特罗凯）和吉非替尼（易瑞沙）的当前认知与未来方向
Oncologist. 2005 Sep;10(8):579-89. doi: 10.1634/theoncologist.10-8-579.
3
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.表皮生长因子受体（EGF）基因突变在“从不吸烟”者的肺癌中很常见，且与肿瘤对吉非替尼和厄洛替尼的敏感性相关。
Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13306-11. doi: 10.1073/pnas.0405220101. Epub 2004 Aug 25.
4
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.表皮生长因子受体中的激活突变是非小细胞肺癌对吉非替尼产生反应的基础。
N Engl J Med. 2004 May 20;350(21):2129-39. doi: 10.1056/NEJMoa040938. Epub 2004 Apr 29.
5
Pathology of lung cancer.肺癌的病理学
Clin Chest Med. 2002 Mar;23(1):65-81, viii. doi: 10.1016/s0272-5231(03)00061-3.
6
Metastatic tumors of the thyroid gland: a study of 79 cases in Chinese patients.甲状腺转移性肿瘤：79例中国患者的研究
Arch Pathol Lab Med. 1998 Jan;122(1):37-41.
7
Metastasis to the thyroid gland. A report of 43 cases.甲状腺转移瘤。43例报告。
Cancer. 1997 Feb 1;79(3):574-8. doi: 10.1002/(sici)1097-0142(19970201)79:3<574::aid-cncr21>3.0.co;2-#.
Zotero 插件