Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, USA.
J Thorac Dis. 2011 Dec;3(4):271-3. doi: 10.3978/j.issn.2072-1439.2011.02.03.
Cancer metastasis to the thyroid is rare. Primary sites that have been reported to metastasize to the thyroid gland include breast and kidney. There are very few case reports describing metastasis of a lung primary cancer to the thyroid gland. We describe a case of a never-smoker patient with metastatic adenocarcinoma of the lung and a malignant thyroid mass presenting simultaneously. The thyroid biopsy could not distinguish whether it was a metastasis or incidentally found thyroid primary carcinoma. Based on EGFR mutational status it was determined that he has a primary lung cancer and thyroid metastasis. He was started on erlotinib and has had a marked response in both the lung and the thyroid masses. The presence of mutations within the EGFR gene can help distinguish lung adenocarcinoma from other carcinomas like thyroid cancer. This is the first published case of primary lung adenocarcinoma with metastasis to thyroid and with EGFR mutation.
癌症转移至甲状腺较为罕见。据报道，有多种原发性肿瘤可转移至甲状腺，包括乳腺和肾脏。仅有少数病例报告描述了原发性肺癌转移至甲状腺。我们描述了一例从未吸烟的患者，其同时患有转移性肺腺癌和甲状腺恶性肿块。甲状腺活检无法区分这是转移灶还是偶然发现的甲状腺原发性癌。根据 EGFR 基因突变状态，确定他患有原发性肺癌和甲状腺转移。他开始接受厄洛替尼治疗，肺部和甲状腺肿块均有明显缓解。EGFR 基因内的突变存在有助于将肺腺癌与其他癌（如甲状腺癌）区分开来。这是首例经 EGFR 基因突变证实的原发性肺腺癌伴甲状腺转移的病例。
