Mitra Sumita B, Oxman Joe D, Falsafi Afshin, Ton Tiffany T
Mitra Chemical Consulting LLC, 1952 Nature View Lane, West St. Paul, MN 55118, USA.
Am J Dent. 2011 Dec;24(6):372-8.
To compare the long-term fluoride release kinetics of a novel nano-filled two-paste resin-modified glass-ionomer (RMGI), Ketac Nano (KN) with that of two powder-liquid resin-modified glass-ionomers, Fuji II LC (FLC) and Vitremer (VT) and one conventional glass-ionomer, Fuji IX (FIX).
Fluoride release was measured in vitro using ion-selective electrodes. Kinetic analysis was done using regression analysis and compared with existing models for GIs and compomers. In a separate experiment the samples of KN and two conventional glass-ionomers, FIX and Ketac Molar (KM) were subjected to a treatment with external fluoride source (Oral-B Neutra-Foam) after 3 months of fluoride release and the recharge behavior studied for an additional 7-day period.
The cumulative amount of fluoride released from KN, VT and FLC and the release profiles were statistically similar but greater than that for FIX at P < 0.05. All four materials, including KN, showed a burst of fluoride ions at shorter times (t) and an overall rate dependence on t1/2 typical for glass-ionomers. The coating of KN with its primer and of DY with its adhesive did not significantly alter the fluoride release behavior of the respective materials. The overall rate for KN was significantly higher than for the compomer DY. DY showed a linear rate of release vs. t and no burst effect as expected for compomers. The nanoionomer KN showed fluoride recharge behavior similar to the conventional glass ionomers FIX and KM. Thus, it was concluded that the new RMGI KN exhibits fluoride ion release behavior similar to typical conventional and RMGIs and that the primer does not impede the release of fluoride.
比较新型纳米填充双糊剂型树脂改性玻璃离子水门汀(RMGI)——Ketac Nano(KN)与两种粉液型树脂改性玻璃离子水门汀Fuji II LC(FLC)和Vitremer(VT)以及一种传统玻璃离子水门汀Fuji IX(FIX)的长期氟释放动力学。
使用离子选择性电极体外测量氟释放量。采用回归分析进行动力学分析,并与现有的玻璃离子水门汀和复合体模型进行比较。在另一项实验中,氟释放3个月后,对KN以及两种传统玻璃离子水门汀FIX和Ketac Molar(KM)的样本用外部氟源(佳洁士防蛀泡沫牙膏)进行处理,并额外研究7天的再充氟行为。
KN、VT和FLC释放的氟累积量及释放曲线在统计学上相似,但在P < 0.05时均大于FIX。包括KN在内的所有四种材料在较短时间(t)均出现氟离子突发释放,且总体释放速率依赖于t1/2,这是玻璃离子水门汀的典型特征。KN与底漆、DY与粘结剂的涂层均未显著改变各自材料的氟释放行为。KN的总体释放速率显著高于复合体DY。DY的释放速率与t呈线性关系,且未出现复合体预期的突发效应。纳米离子水门汀KN表现出与传统玻璃离子水门汀FIX和KM相似的再充氟行为。因此,得出结论:新型RMGI KN表现出与典型传统玻璃离子水门汀和RMGI相似的氟离子释放行为,且底漆不会阻碍氟的释放。