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碲化镉量子点纳米颗粒的细胞毒性及其对铜绿假单胞菌模型免疫反应的影响。

Cadmium telluride quantum dot nanoparticle cytotoxicity and effects on model immune responses to Pseudomonas aeruginosa.

机构信息

Biotechnology Laboratory, Mechanistic Studies Division, Environmental Health Science and Research Bureau , Health Canada, Ottawa, Ontario , Canada.

出版信息

Nanotoxicology. 2013 Mar;7(2):202-11. doi: 10.3109/17435390.2011.648667. Epub 2012 Jan 20.

DOI:10.3109/17435390.2011.648667
PMID:22264036
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3581059/
Abstract

This study examines dose effects of cadmium telluride quantum dots (CdTe-QDs) from two commercial sources on model macrophages (J774A.1) and colonic epithelial cells (HT29). Effects on cellular immune signalling responses were measured following sequential exposure to QDs and Pseudomonas aeruginosa strain PA01. At CdTe-QD concentrations between 10(-2) and 10 µg/ml, cells exhibited changes in metabolism and morphology. Confocal imaging revealed QD internalisation and changes in cell-cell contacts, shapes and internal organisations. QD doses below 10(-2) µg/ml caused no observed effects. When QD exposures at 10(-7) to 10(-3) µg/ml preceded PA01 (10(7) bacteria/ml) challenges, there were elevated cytotoxicity (5-22%, p < 0.05) and reduced levels (two- to fivefold, p < 0.001) of nitric oxide (NO), TNF-α, KC/CXC-1 and IL-8, compared with PA01 exposures alone. These results demonstrate that exposures to sub-toxic levels of CdTe-QDs can depress cell immune-defence functions, which if occurred in vivo would likely interfere with normal neutrophil recruitment for defence against bacteria.

摘要

本研究考察了两种商业来源的碲化镉量子点（CdTe-QDs）对模型巨噬细胞（J774A.1）和结肠上皮细胞（HT29）的剂量效应。在连续暴露于量子点和铜绿假单胞菌 PA01 后，测量了对细胞免疫信号反应的影响。在 10(-2)至 10 µg/ml 的 CdTe-QD 浓度下，细胞表现出代谢和形态的变化。共聚焦成像显示 QD 的内化以及细胞-细胞接触、形状和内部组织的变化。QD 剂量低于 10(-2) µg/ml 时未观察到明显影响。当 QD 暴露于 10(-7)至 10(-3) µg/ml 时，随后进行 10(7)个细菌/ml 的 PA01 挑战，与单独暴露于 PA01 相比，细胞毒性（5-22%，p<0.05）和一氧化氮（NO）、TNF-α、KC/CXC-1 和 IL-8 的水平降低（两到五倍，p<0.001）。这些结果表明，暴露于亚毒性水平的 CdTe-QDs 会抑制细胞免疫防御功能，如果在体内发生，可能会干扰正常中性粒细胞对细菌的防御招募。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/366d/3581059/5afe5748d06a/NAN-7-202-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/366d/3581059/5afe5748d06a/NAN-7-202-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/366d/3581059/144dfe403c6d/NAN-7-202-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/366d/3581059/e2cd41533115/NAN-7-202-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/366d/3581059/1dcddad44e19/NAN-7-202-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/366d/3581059/1292f25e14c4/NAN-7-202-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/366d/3581059/3c7a5e0e1319/NAN-7-202-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/366d/3581059/5afe5748d06a/NAN-7-202-g007.jpg

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