静脉注射维生素 C 可减轻上班族的疲劳：一项双盲随机对照试验。
Intravenous vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial.
机构信息
Department of Family Medicine, Dongguk University Ilsan Hospital, Goyangsi, Gyeonggi-do, Republic of Korea.
出版信息
Nutr J. 2012 Jan 20;11:7. doi: 10.1186/1475-2891-11-7.
BACKGROUND
Studies of the efficacy of vitamin C treatment for fatigue have yielded inconsistent results. One of the reasons for this inconsistency could be the difference in delivery routes. Therefore, we planned a clinical trial with intravenous vitamin C administration.
METHODS
We evaluated the effect of intravenous vitamin C on fatigue in office workers. A group of 141 healthy volunteers, aged 20 to 49 years participated in this randomized, double-blind, controlled clinical trial. The trial group received 10 grams of vitamin C with normal saline intravenously, while the placebo group received normal saline only. Since vitamin C is a well-known antioxidant, oxidative stress was measured. Fatigue score, oxidative stress, and plasma vitamin C levels were measured before intervention, and again two hours and one day after intervention. Adverse events were monitored.
RESULTS
The fatigue scores measured at two hours after intervention and one day after intervention were significantly different between the two groups (p = 0.004); fatigue scores decreased in the vitamin C group after two hours and remained lower for one day. Trial also led to higher plasma vitamin C levels and lower oxidative stress compared to the placebo group (p < 0.001, p < 0.001, respectively). When data analysis was refined by dividing each group into high-baseline and low-baseline subgroups, it was observed that fatigue was reduced in the lower baseline vitamin C level group after two hours and after one day (p = 0.004). The same did not hold for the higher baseline group (p = 0.206).
CONCLUSION
Thus, intravenous vitamin C reduced fatigue at two hours, and the effect persisted for one day. There were no significant differences in adverse events between two groups. High dose intravenous vitamin C proved to be safe and effective against fatigue in this study.
TRIAL REGISTRATION
The clinical trial registration of this trial is http://ClinicalTrials.govNCT00633581.
背景
维生素 C 治疗疲劳的疗效研究结果不一致。造成这种不一致的原因之一可能是给药途径的差异。因此，我们计划进行一项静脉注射维生素 C 治疗的临床试验。
方法
我们评估了静脉注射维生素 C 对上班族疲劳的影响。141 名年龄在 20 岁至 49 岁之间的健康志愿者参与了这项随机、双盲、对照临床试验。试验组给予 10 克维生素 C 与生理盐水静脉滴注，对照组仅给予生理盐水。由于维生素 C 是一种众所周知的抗氧化剂，我们测量了氧化应激。在干预前、干预后两小时和一天后测量疲劳评分、氧化应激和血浆维生素 C 水平。监测不良反应。
结果
干预后两小时和一天后两组的疲劳评分差异有统计学意义（p = 0.004）；维生素 C 组在干预后两小时疲劳评分下降，且持续一天。与安慰剂组相比，试验还导致血浆维生素 C 水平升高和氧化应激降低（p < 0.001，p < 0.001）。将每组按基线维生素 C 水平高低分为高基线和低基线亚组进行数据分析时，发现低基线维生素 C 水平组在干预后两小时和一天后疲劳减轻（p = 0.004）。高基线组则不然（p = 0.206）。
结论
因此，静脉注射维生素 C 可在两小时内减轻疲劳，且效果持续一天。两组间不良反应无显著差异。高剂量静脉注射维生素 C 在本研究中对疲劳是安全有效的。
试验注册
该试验的临床试验注册信息为 http://ClinicalTrials.govNCT00633581。
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