拓展形态发生谱：来自果蝇卵子的观点。
Expanding the morphogenetic repertoire: perspectives from the Drosophila egg.
机构信息
Department of Molecular & Cell Biology, 379 Life Sciences Addition #3200, University of California, Berkeley, Berkeley, CA 94720-3200, USA.
出版信息
Dev Cell. 2012 Jan 17;22(1):12-23. doi: 10.1016/j.devcel.2011.12.003.
Abstract
Tissue and organ architectures are incredibly diverse, yet our knowledge of the morphogenetic behaviors that generate them is relatively limited. Recent studies have revealed unexpected mechanisms that drive axis elongation in the Drosophila egg, including an unconventional planar polarity signaling pathway, a distinctive type of morphogenetic movement termed "global tissue rotation," a molecular corset-like role of extracellular matrix, and oscillating basal cellular contractions. We review here what is known about Drosophila egg elongation, compare it to other instances of morphogenesis, and highlight several issues of general developmental relevance.
摘要
组织和器官结构极其多样，但我们对生成它们的形态发生行为的了解相对有限。最近的研究揭示了驱动果蝇卵子轴伸长的出乎意料的机制，包括一种非传统的平面极性信号通路、一种称为“整体组织旋转”的独特形态发生运动类型、细胞外基质的分子紧身胸衣样作用以及基底细胞的振荡收缩。我们在这里回顾了已知的果蝇卵子伸长情况，将其与其他形态发生实例进行了比较，并强调了几个具有普遍发育相关性的问题。
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