Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.
Trends Neurosci. 2012 Apr;35(4):250-60. doi: 10.1016/j.tins.2011.12.005. Epub 2012 Jan 19.
Addiction is a chronic relapsing disorder associated with compulsive drug taking, drug seeking and a loss of control in limiting intake, reflected in three stages of a recurrent cycle: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation ("craving"). This review discusses the role of adult-born neural and glial progenitors in drug seeking associated with the different stages of the addiction cycle. A review of the current literature suggests that the loss of newly born progenitors, particularly in hippocampal and cortical regions, plays a role in determining vulnerability to relapse in rodent models of drug addiction. The normalization of drug-impaired neurogenesis or gliogenesis may help reverse neuroplasticity during abstinence and, thus, may help reduce the vulnerability to relapse and aid recovery.
成瘾是一种慢性复发性疾病，与强迫性药物使用、觅药和控制摄入的能力丧失有关，反映在反复发作周期的三个阶段：狂欢/陶醉、戒断/负性情绪和专注/期待（“渴望”）。这篇综述讨论了成年神经和神经胶质前体细胞在与成瘾周期不同阶段相关的觅药中的作用。对现有文献的回顾表明，新产生的祖细胞的丧失，特别是在海马和皮质区域，在确定对药物成瘾的啮齿动物模型中复发性的易感性方面起着重要作用。药物损伤的神经发生或神经胶质发生的正常化可能有助于逆转戒断期间的神经可塑性，从而可能有助于降低复发性的易感性并有助于恢复。
