College of Optometry, University of Houston, Houston, Texas, USA.
Invest Ophthalmol Vis Sci. 2012 Mar 9;53(3):1315-23. doi: 10.1167/iovs.11-8461. Print 2012 Mar.
To use the photopic electroretinogram (ERG) to evaluate retinal function in eyes of multiple sclerosis (MS) patients with and without a history of optic neuritis (ON) and to compare the functional and structural status of the inner retina.
Full-field ERG responses to brief red flashes (0.04-2.8 cd · s/m²) on a rod-saturating blue background were recorded from 51 MS patients and 33 age-matched control subjects. In patients, perimetry was performed and peripapillary retinal nerve fiber layer thickness (RNFLT) was assessed by optical coherence tomography (OCT) and scanning laser polarimetry (SLP). MS eyes were separated into groups: "ON >6" months (n = 25), "ON <6" months (n = 29), and "no ON" (n = 33) based on positive or negative history of ON and time since the last episode. Thirteen ON<6 eyes were re-evaluated 1 year later.
PhNR amplitudes were lower in ON>6, ON<6, and no-ON eyes (mean ± SD, 17.3 ± 7.6, 16.0 ± 6.5, and 23.8 ± 9.3 μV, respectively), than in control eyes (29.8 ± 6.5 μV; P < 0.001) for a standard stimulus of 1.42 cd · s/m²; a- and b-wave amplitudes were unaffected. PhNR amplitudes correlated with visual fields mean deviation (MD) in ON>6 (r² = 0.43; P < 0.001) and no-ON eyes (r² = 0.10; P < 0.05), with similar results for weaker stimuli. PhNR amplitudes correlated with RNFLT in ON>6 eyes: OCT (r² = 0.52; P < 0.0001) and SLP (r² = 0.51; P < 0.01); and in no-ON eyes, OCT (r² = 0.21; P < 0.01) and SLP (r² = 0.17; P < 0.05). ON<6 amplitudes did not correlate significantly with other measures, but increased after 1 year by 5.1 ± 3.1 μV (P < 0.001), visual fields MD increased by 1.8 ± 2.3 dB (P < 0.05), and RNFL loss persisted.
Photopic ERG PhNR amplitudes in MS patients are significantly reduced in eyes with and without a history of ON.
使用明视视网膜电图（ERG）评估多发性硬化症（MS）患者伴或不伴视神经炎（ON）病史的视网膜功能，并比较内视网膜的功能和结构状态。
对 51 例 MS 患者和 33 名年龄匹配的对照者进行了短暂红光闪烁（0.04-2.8 cd·s/m²）的全视野 ERG 反应记录，这些红光在蓝光背景下刺激视杆细胞，使其达到饱和。在患者中，进行了视野检查，并通过光学相干断层扫描（OCT）和扫描激光偏振计（SLP）评估了视乳头周围神经纤维层厚度（RNFLT）。根据 ON 的阳性或阴性病史以及最后一次发作后的时间，将 MS 眼分为三组：“ON>6 个月”（n=25）、“ON<6 个月”（n=29）和“无 ON”（n=33）。对 13 例 ON<6 个月的眼在 1 年后进行了重新评估。
ON>6、ON<6 和无 ON 眼的 PhNR 振幅（分别为 17.3±7.6、16.0±6.5 和 23.8±9.3 μV）比对照眼（29.8±6.5 μV；P<0.001）低，刺激强度为 1.42 cd·s/m²；a-和 b-波振幅不受影响。PhNR 振幅与 ON>6（r²=0.43；P<0.001）和无 ON 眼（r²=0.10；P<0.05）的视野平均偏差（MD）相关，对较弱的刺激也有类似的结果。PhNR 振幅与 ON>6 眼的 RNFLT 相关：OCT（r²=0.52；P<0.0001）和 SLP（r²=0.51；P<0.01）；与无 ON 眼的 OCT（r²=0.21；P<0.01）和 SLP（r²=0.17；P<0.05）相关。ON<6 眼的振幅与其他测量值无显著相关性，但在 1 年后增加了 5.1±3.1 μV（P<0.001），视野 MD 增加了 1.8±2.3 dB（P<0.05），并且 RNFL 丢失持续存在。
伴有或不伴有 ON 病史的 MS 患者的明视视网膜电图 PhNR 振幅明显降低。
