Fraser Clare L, Holder Graham E
Department of Neuro-Ophthalmology, Moorfields Eye Hospital, and Institute of Ophthalmology, University College London, 162 City Road, London, EC1V 2PD, UK.
Doc Ophthalmol. 2011 Dec;123(3):173-8. doi: 10.1007/s10633-011-9294-x. Epub 2011 Oct 30.
To report the electrophysiological findings in patients with unilateral optic neuritis (ON), with particular reference to the electroretinogram (ERG). A retrospective analysis of full-field ERG, pattern ERG (PERG) and pattern visual evoked potential findings from 46 patients with clinical and electrophysiological findings in keeping with unilateral ON. ISCEV standard ERGs did not significantly differ between the optic neuritis and fellow eyes, nor between patients with and without MS. Differences were present in the N95 component of the PERG, which was significantly lower in the affected eye, and the pattern reversal visual evoked potential, which showed significantly longer peak time (latency) in the affected eye. In addition, there was a significant difference between patients with and without multiple sclerosis (MS). No significant inter-ocular asymmetry in ISCEV standard ERGs was present in these cases of unilateral optic neuritis, either as a clinically isolated syndrome or as part of multiple sclerosis. All ERGs recorded were normal.
报告单侧视神经炎（ON）患者的电生理检查结果，尤其涉及视网膜电图（ERG）。对46例临床和电生理检查结果符合单侧ON的患者的全视野ERG、图形视网膜电图（PERG）和图形视觉诱发电位结果进行回顾性分析。视神经炎患眼与对侧眼之间，以及合并或未合并多发性硬化（MS）的患者之间，国际临床视觉电生理学会（ISCEV）标准ERG均无显著差异。PERG的N95成分存在差异，患眼该成分显著降低；图形翻转视觉诱发电位也存在差异，患眼的峰时间（潜伏期）显著延长。此外，合并和未合并MS的患者之间存在显著差异。在这些单侧视神经炎病例中，无论是作为临床孤立综合征还是作为MS的一部分，ISCEV标准ERG均未出现显著的双眼不对称。所有记录的ERG均正常。
