Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, MD, USA.
Bioinformatics. 2012 Mar 15;28(6):897-9. doi: 10.1093/bioinformatics/bts040. Epub 2012 Jan 27.
The synapse is integral to the function of the brain and may be an important source of dysfunction underlying many neuropsychiatric disorders. Consequently, it is an excellent candidate for large-scale genomic and proteomic study. However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking.
We present an integrated database, called SynaptomeDB, to retrieve and annotate genes comprising the synaptome. These genes encode components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins, scaffold proteins, membrane transporters. SynaptomeDB integrates various and complex data sources for synaptic genes and proteins.
突触对于大脑的功能至关重要，并且可能是许多神经精神疾病功能障碍的重要来源。因此，它是大规模基因组和蛋白质组学研究的理想候选对象。然而，尽管用于注释高通量 DNA 和蛋白质的工具和数据库通常功能强大，但缺乏专门用于整合有关突触信息的综合资源。
我们提出了一个名为 SynaptomeDB 的综合数据库，用于检索和注释组成突触体的基因。这些基因编码包括神经递质及其受体、黏附/细胞骨架蛋白、支架蛋白、膜转运蛋白在内的突触成分。SynaptomeDB 整合了突触基因和蛋白质的各种复杂数据源。
