PD-L1/PD-1 在呼吸道病毒感染免疫反应中的作用。
Role of PD-L1/PD-1 in the immune response to respiratory viral infections.
机构信息
Oncology Institute Prof. Dr. Ion Chiricuta, Department of Hematology, and University of Medicine and Pharmacy, Cluj-Napoca, Romania.
出版信息
Microbes Infect. 2012 Jun;14(6):495-9. doi: 10.1016/j.micinf.2012.01.002. Epub 2012 Jan 18.
PMID:22285902
Abstract
Airway epithelial cells are the main cells infected by respiratory viruses including rhinoviruses and respiratory syncytial virus. Virus modulation of inhibitory molecule PD-L1 on epithelial cells may be important in limiting anti-viral effector CD8(+) T cell responses and, consequently, worsening acute virus-induced lung tissue damage.
摘要
气道上皮细胞是呼吸道病毒（包括鼻病毒和呼吸道合胞病毒）感染的主要细胞。病毒对上皮细胞抑制性分子 PD-L1 的调节可能对限制抗病毒效应 CD8(+) T 细胞反应很重要，从而导致急性病毒引起的肺组织损伤加重。
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