Kashte Shivaji, Jaiswal Amit Kumar, Kadam Sachin
1Department of Biosciences and Technology, Defence Institute of Advanced Technology, Girinagar, Pune, MS 411025 India.
3Center for Interdisciplinary Research, D. Y. Patil University, Kolhapur, 416006 India.
Tissue Eng Regen Med. 2017 Jan 17;14(1):1-14. doi: 10.1007/s13770-016-0001-6. eCollection 2017 Feb.
Bone provides mechanical support, and flexibility to the body as a structural frame work along with mineral storage, homeostasis, and blood pH regulation. The repair and/or replacement of injured or defective bone with healthy bone or bone substitute is a critical problem in orthopedic treatment. Recent advances in tissue engineering have shown promising results in developing bone material capable of substituting the conventional autogenic or allogenic bone transplants. In the present review, we have discussed natural and synthetic scaffold materials such as metal and metal alloys, ceramics, polymers, etc. which are widely being used along with their cellular counterparts such as stem cells in bone tissue engineering with their pros and cons.
骨骼作为身体的结构框架,提供机械支撑和柔韧性,同时还具有矿物质储存、内环境稳定和血液pH调节功能。用健康的骨骼或骨替代物修复和/或替换受损或有缺陷的骨骼是骨科治疗中的一个关键问题。组织工程学的最新进展在开发能够替代传统自体或异体骨移植的骨材料方面显示出了令人鼓舞的结果。在本综述中,我们讨论了天然和合成支架材料,如金属及金属合金、陶瓷、聚合物等,这些材料在骨组织工程中与细胞对应物(如干细胞)一起被广泛使用,并阐述了它们的优缺点。