Hunter P R
Public Health Laboratory, City Hospital, Chester, United Kingdom.
J Clin Microbiol. 1990 Sep;28(9):1903-5. doi: 10.1128/jcm.28.9.1903-1905.1990.
When microbial strain-typing methods are compared, the most important characteristics are typeability, reproducibility, and discriminatory power. While typeability and reproducibility can be presented as numerical values, indices of discriminatory power have only recently been described. This paper examines the relationship between reproducibility and indices of discriminatory power. In an individual typing method, an inverse relationship between reproducibility and discriminatory power appears as the number of test differences required in order to distinguish between strains is increased. A method of standardizing the discriminatory power of a typing method to a predetermined reproducibility is presented. In this way the discriminatory powers of different typing methods can be compared while being standardized for the effect of reproducibility.
在比较微生物菌株分型方法时，最重要的特性是分型能力、可重复性和鉴别力。虽然分型能力和可重复性可以用数值表示，但鉴别力指数直到最近才被描述。本文研究了可重复性与鉴别力指数之间的关系。在单一分型方法中，随着区分菌株所需测试差异数量的增加，可重复性与鉴别力之间呈现出反比关系。本文提出了一种将分型方法的鉴别力标准化为预定可重复性的方法。通过这种方式，可以在对可重复性的影响进行标准化的同时，比较不同分型方法的鉴别力。
