School of Resource and Environmental Engineering/Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, PR China.
Environ Toxicol Pharmacol. 2012 Mar;33(2):344-52. doi: 10.1016/j.etap.2011.12.024. Epub 2012 Jan 3.
The acute and chronic toxicological effects of carbamazepine (CBZ) on Scenedesmus obliquus and Chlorella pyrenoidosa were explored for the first time in this study. The results showed that CBZ could significantly inhibit the growth of the two algae in almost all treatment groups. EC(50) values indicated that, CBZ had a relatively limited acute toxic effect (0-144 h) on S. obliquus and C. pyrenoidosa, while, chronic tests (5-30 d) displayed higher toxicity. Chlorophyll a syntheses were nearly all inhibited by CBZ exposure. However, superoxide dismutase (SOD) and catalase (CAT) activities in acute tests of both algae were markedly promoted. According to the results, Chlorophyll a content and CAT activity of S. obliquus were more sensitive to CBZ than that of C. pyrenoidosa. While for SOD, quite to the contrary, C. pyrenoidosa was more vulnerable. We obtained a similar result in chronic tests. This research furthers our understanding of CBZ toxicity to aquatic organisms.
本研究首次探讨了卡马西平（CBZ）对斜生栅藻和蛋白核小球藻的急性和慢性毒理学效应。结果表明，CBZ 几乎能在所有实验组中显著抑制两种藻类的生长。EC（50）值表明，CBZ 对斜生栅藻和蛋白核小球藻的急性毒性（0-144 h）相对有限，而慢性试验（5-30 d）则显示出更高的毒性。CBZ 暴露几乎抑制了所有叶绿素 a 的合成。然而，两种藻类的急性试验中超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的活性明显增强。根据结果，叶绿素 a 含量和 CAT 活性对 CBZ 的敏感程度斜生栅藻高于蛋白核小球藻。而对于 SOD，则恰恰相反，蛋白核小球藻更为脆弱。在慢性试验中我们得到了类似的结果。本研究进一步加深了我们对 CBZ 对水生生物毒性的理解。
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