Zahmatkash Mohsen, Vafaeenasab Mohammad Reza
Farateb Research Institute, Yazd, Iran.
Pak J Biol Sci. 2011 Jul 1;14(13):715-9. doi: 10.3923/pjbs.2011.715.719.
Knee osteoarthritis is the most common cause of disability among people and it is a common disease of joints that can lead to cartilage damage. In this study the analgesic effects of a herbal ointment containing cinnamon, ginger, mastic (Saghez) and sesame oil is compared with Salicylate ointment in patients suffering from knee osteoarthritis. It was a double-blind randomized controlled trail study. Patients with diagnosed arthritis were involved in the study and they were divided in two groups via block randomization method. For six weeks, twice a day, intervention group applied herbal ointment and control group used Salicylate ointment. The severity of pain, morning stiffness and limited motion were measured using Visual Analog Pain Scale. In order to analyze the trends of these three indexes, repeated measurement test was used. Ninety two participates with the mean age of 52.2 (+/- 12.4) years and with the mean disease period of 30.45 (+/- 30.3) months were involved in the study. There was no significant difference between two groups regarding the distribution of sex, weight, height, BMI and the duration of illness. No statistical difference was observed between two groups regarding pain relief, morning stiffness and limited motion; nevertheless in repeated measurements during second, forth and sixth weeks in both groups the decreasing trend of these three indexes had been statistically significant (p < 0.0001). It seems that using this herbal combination is clinically effective for patients suffering from knee osteoarthritis in order to decrease their pain, morning stiffness and limited motion; its effect is comparable with Salicylate ointment.
膝关节骨关节炎是导致人们残疾的最常见原因，它是一种常见的关节疾病，可导致软骨损伤。在本研究中，将一种含有肉桂、生姜、乳香（萨赫兹）和芝麻油的草药软膏与水杨酸盐软膏对膝关节骨关节炎患者的镇痛效果进行了比较。这是一项双盲随机对照试验研究。确诊为关节炎的患者参与了该研究，并通过区组随机化方法将他们分为两组。六周内，干预组每天两次涂抹草药软膏，对照组使用水杨酸盐软膏。使用视觉模拟疼痛量表测量疼痛的严重程度、晨僵和活动受限情况。为了分析这三个指标的变化趋势，采用了重复测量检验。92名平均年龄为52.2（±12.4）岁、平均病程为30.45（±30.3）个月的参与者参与了该研究。两组在性别、体重、身高、BMI和病程分布方面无显著差异。两组在疼痛缓解、晨僵和活动受限方面未观察到统计学差异；然而，在两组的第二、第四和第六周的重复测量中，这三个指标的下降趋势具有统计学意义（p<0.0001）。看来，使用这种草药组合对膝关节骨关节炎患者在减轻疼痛、晨僵和活动受限方面具有临床疗效；其效果与水杨酸盐软膏相当。
