Pakale Dr Prathamesh V, Khanwelkar Chitra, Thorat Vandana, Jadhav Sujata, Tiwari Devkumar D
Department of Pharmacology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Cureus. 2024 Nov 22;16(11):e74219. doi: 10.7759/cureus.74219. eCollection 2024 Nov.
Introduction The study was done to evaluate the analgesic activity of the aqueous and methanolic extracts of fresh rhizome of . The study objectives included evaluating and comparing the analgesic activity of both extracts at two different doses with that of the standard drug (aspirin) in Wistar rats using the rat tail-flick method. Method The study was conducted after receiving approval from the animal ethics committee. The animals were divided into six groups of six rats each. The control group received 0.2 ml normal saline IP whereas the test groups received aspirin (150 mg/kg), aqueous extract of fresh rhizome of (100 and 200mg/kg), and methanolic extract of fresh rhizome of (100 and 200 mg/kg). The rat tail-flick method was used to investigate the analgesic activity. Result The present study clearly showed the significant analgesic activity of the aqueous and methanolic extracts of fresh rhizome of (p<0.05) via the rat tail-flick method compared to the control. Moreover, their activities were comparable to aspirin. Conclusion The aqueous and methanolic extracts of have significant analgesic activity properties.
引言 本研究旨在评估[植物名称]新鲜根茎水提取物和甲醇提取物的镇痛活性。研究目的包括使用大鼠甩尾法，在Wistar大鼠中评估和比较两种提取物在两种不同剂量下与标准药物（阿司匹林）的镇痛活性。方法 本研究在获得动物伦理委员会批准后进行。将动物分为六组，每组六只大鼠。对照组腹腔注射0.2 ml生理盐水，而试验组分别给予阿司匹林（150 mg/kg）、[植物名称]新鲜根茎水提取物（100和200 mg/kg）以及[植物名称]新鲜根茎甲醇提取物（100和200 mg/kg）。采用大鼠甩尾法研究镇痛活性。结果 本研究通过大鼠甩尾法清楚地表明，与对照组相比，[植物名称]新鲜根茎水提取物和甲醇提取物具有显著的镇痛活性（p<0.05）。此外，它们的活性与阿司匹林相当。结论 [植物名称]的水提取物和甲醇提取物具有显著的镇痛活性特性。
