Martinez Alberto R M, Nunes Marcelo B, Nucci Anamarli, França Marcondes C
Department of Neurology, Faculty of Medicine, University of Campinas (UNICAMP), 13083-887 Campinas, SP, Brazil.
Autoimmune Dis. 2012;2012:873587. doi: 10.1155/2012/873587. Epub 2012 Jan 19.
Sensory neuronopathies (SNs) are a specific subgroup of peripheral nervous system diseases characterized by primary degeneration of dorsal root ganglia and their projections. Multifocal sensory symptoms often associated to ataxia are the classical features of SN. Several different etiologies have been described for SNs, but immune-mediated damage plays a key role in most cases. SN may herald the onset of some systemic autoimmune diseases, which further emphasizes how important the recognition of SN is in clinical practice. We have thus reviewed available clinical, neurophysiological, and therapeutic data on autoimmune disease-related SN, namely, in patients with Sjögren's syndrome, autoimmune hepatitis, and celiac disease.
感觉神经元病（SNs）是周围神经系统疾病的一个特定亚组，其特征是背根神经节及其投射的原发性变性。多灶性感觉症状常伴有共济失调，是SN的典型特征。SNs有几种不同的病因，但免疫介导的损伤在大多数情况下起关键作用。SN可能预示着某些系统性自身免疫性疾病的发作，这进一步强调了在临床实践中识别SN的重要性。因此，我们回顾了有关自身免疫性疾病相关SN的现有临床、神经生理学和治疗数据，即干燥综合征、自身免疫性肝炎和乳糜泻患者的数据。
