Clinical and Experimental Sciences, University of Southampton, Hampshire, UK.
Curr Opin Clin Nutr Metab Care. 2012 Mar;15(2):127-33. doi: 10.1097/MCO.0b013e32834fb003.
Lipidomics characterizes the composition of intact lipid molecular species in biological systems and the field has been driven by some spectacular advances in mass spectrometry instrumentation and applications. This review will highlight these advances and outline their recent application to address clinical issues.
This review first identifies recent advances in lipid detection and analysis by a variety of mass spectrometry techniques, then reviews specific application including stable isotope labelling of lipids, lipid mass spectrometry imaging, data analysis and bioinformatics, and finally presents examples of the application of lipidomics to selected disease states.
Lipidomics so far has been principally concerned with identifying novel methodologies, but recent advances demonstrating applications in diabetes, neurodegenerative diseases, cystic fibrosis and other respiratory diseases clearly indicate the potential usefulness of lipidomics both to generate biomarkers of disease and to probe signalling and metabolic processes.
脂质组学描述了生物系统中完整脂质分子种类的组成，该领域受到质谱仪器和应用方面一些显著进展的推动。本综述将重点介绍这些进展，并概述它们最近在解决临床问题方面的应用。
本综述首先确定了各种质谱技术在脂质检测和分析方面的最新进展，然后综述了特定的应用，包括脂质的稳定同位素标记、脂质质谱成像、数据分析和生物信息学，最后介绍了脂质组学在选定疾病状态中的应用实例。
迄今为止，脂质组学主要关注于识别新方法，但最近的进展表明其在糖尿病、神经退行性疾病、囊性纤维化和其他呼吸道疾病中的应用潜力，这清楚地表明脂质组学在生成疾病生物标志物和探索信号转导和代谢过程方面都具有潜在的用处。
