Anzai E, Shiozawa Z, Shindo K, Tsunoda S, Koizumi K, Uchiyama G
Third Department of Medicine, Yamanashi Medical University.
Kaku Igaku. 1990 Aug;27(8):863-7.
We examined the 123I-iodoamphetamine SPECT for 3 patients with ALS, who were clinically diagnosed. Patient 1 was a 31-years-old man, who had bilateral muscle weakness of his upper extremities, and spasticity in lower extremities. Patient 2 was a 51-years-old woman, who had marked weakness of her upper extremities and bulbar sign. Patient 3 was a 68-years-old man, who had severe degree of marked weakness of his upper extremities and mild bulbar signs. Cerebral cognitive function were all normal in three patients. Computed tomographic and magnetic resonance imagings showed moderate degree of cortical atrophy in patient 1, but no abnormalities in patients 2 and 3. In 123I-IMP SPECT, however, hypoperfusion were recognized on the bilateral fronto-parietal border zone areas in these three patients with ALS. It was suggested that patients with ALS showed varying degrees of impaired perfusion in the fronto-parietal border zone areas in spite of normal cognitive functions.
我们对3例临床诊断为肌萎缩侧索硬化症（ALS）的患者进行了123I-碘安非他明单光子发射计算机断层扫描（SPECT）检查。患者1为一名31岁男性，上肢双侧肌肉无力，下肢痉挛。患者2为一名51岁女性，上肢明显无力且有延髓体征。患者3为一名68岁男性，上肢严重无力且有轻度延髓体征。三名患者的脑认知功能均正常。计算机断层扫描和磁共振成像显示，患者1有中度皮质萎缩，而患者2和3无异常。然而，在123I-碘安非他明（123I-IMP）SPECT检查中，这3例ALS患者双侧额顶叶交界区均出现灌注减低。提示ALS患者尽管认知功能正常，但额顶叶交界区存在不同程度的灌注受损。
