University of Zaragoza, Spain.
Br J Ophthalmol. 2012 May;96(5):665-70. doi: 10.1136/bjophthalmol-2011-300916. Epub 2012 Feb 10.
To report normal reference values for peripapillary retinal nerve fibre layer (RNFL) thickness and optic disc parameters in children from a community population.
The authors performed a cross-sectional study examining RNFL and optic nerve head (ONH) properties in 358 children aged between 6 and 13 years with no ocular disease. All children underwent an ophthalmic examination that included visual acuity (logMAR), stereopsis assessment (TNO) and optical coherence tomography (Cirrus OCT Zeiss, 'Optic Disc Cube 200×200' protocol). One eye from each subject selected at random was finally analysed. The authors evaluated the influence of height, gender and age on measurements.
High-quality scan data were obtained from 357 children and 344 were finally included. The mean age (SD) was 9.16 (1.7) years and the mean (SD) RNFL average thickness was 98.46 (10.79) μm. The temporal quadrant showed the thinnest RNFL (69.35±11.28 μm), followed by the nasal (71.30±13.45 μm), superior (123.65±19.49 μm) and inferior (130.18±18.13 μm) quadrants. The mean rim area (SD) and disc area (SD) were 1.59 (0.33) and 2.05 (0.39) mm(2), respectively. The average cup to disc (C:D) ratio (SD) was 0.43 (0.19). The authors found no differences in any of the parameters with regard to weight, height and gender.
This study demonstrates normative values of RNFL thickness and ONH parameters in a sample of Caucasian children from the general population.
报告社区人群中儿童的视盘周围视网膜神经纤维层（RNFL）厚度和视盘参数的正常参考值。
作者对 358 名年龄在 6 至 13 岁之间、无眼部疾病的儿童进行了一项横断面研究，检查了他们的 RNFL 和视乳头（ONH）特性。所有儿童均接受了眼科检查，包括视力（logMAR）、立体视评估（TNO）和光学相干断层扫描（Cirrus OCT Zeiss，“Optic Disc Cube 200×200”协议）。最终分析了随机选择的每个受试者的一只眼。作者评估了身高、性别和年龄对测量结果的影响。
从 357 名儿童中获得了高质量的扫描数据，最终有 344 名儿童被纳入研究。平均年龄（SD）为 9.16（1.7）岁，平均（SD）RNFL 平均厚度为 98.46（10.79）μm。颞象限的 RNFL 最薄（69.35±11.28 μm），其次是鼻侧（71.30±13.45 μm）、上方（123.65±19.49 μm）和下方（130.18±18.13 μm）象限。平均边缘面积（SD）和视盘面积（SD）分别为 1.59（0.33）和 2.05（0.39）mm²，平均杯盘比（C：D）（SD）为 0.43（0.19）。作者发现，在体重、身高和性别方面，这些参数没有差异。
本研究展示了来自一般人群的白种人儿童的 RNFL 厚度和 ONH 参数的正常值。
