Abedon Stephen T, Kuhl Sarah J, Blasdel Bob G, Kutter Elizabeth Martin
Department of Microbiology; The Ohio State University; Mansfield, OH USA.
Bacteriophage. 2011 Mar;1(2):66-85. doi: 10.4161/bact.1.2.15845.
Phages as bactericidal agents have been employed for 90 years as a means of treating bacterial infections in humans as well as other species, a process known as phage therapy. In this review we explore both the early historical and more modern use of phages to treat human infections. We discuss in particular the little-reviewed French early work, along with the Polish, US, Georgian and Russian historical experiences. We also cover other, more modern examples of phage therapy of humans as differentiated in terms of disease. In addition, we provide discussions of phage safety, other aspects of phage therapy pharmacology, and the idea of phage use as probiotics.
作为杀菌剂的噬菌体已被用作治疗人类及其他物种细菌感染的手段长达90年，这一过程被称为噬菌体疗法。在本综述中，我们探讨了噬菌体治疗人类感染的早期历史及更现代的应用。我们特别讨论了较少被回顾的法国早期研究，以及波兰、美国、格鲁吉亚和俄罗斯的历史经验。我们还涵盖了其他更现代的人类噬菌体治疗实例，并按疾病进行了区分。此外，我们还讨论了噬菌体安全性、噬菌体治疗药理学的其他方面，以及将噬菌体用作益生菌的想法。
