School of Chemistry, University of Southampton, Southampton, Hampshire, UK.
ChemSusChem. 2012 Feb 13;5(2):326-31. doi: 10.1002/cssc.201100601.
A general procedure for the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-mediated electrooxidation of primary and secondary alcohols modified for application in a microfluidic electrolytic cell is described. The electrocatalytic system utilises a buffered aqueous tert-butanol reaction medium, which operates effectively without the requirement for additional electrolyte, providing a mild protocol for the oxidation of alcohols to aldehydes and ketones at ambient temperature on a laboratory scale. Optimisation of the process is discussed along with the oxidation of 15 representative alcohols.
介绍了一种改良的适用于微流电解池的 2,2,6,6-四甲基哌啶-1-氧基（TEMPO）介导的伯醇和仲醇的电化学氧化的通用程序。该电催化体系利用缓冲的叔丁醇水溶液反应介质，无需额外电解质即可有效运行，为在实验室规模下于环境温度下将醇氧化为醛和酮提供了温和的方案。讨论了该工艺的优化以及 15 种代表性醇的氧化情况。
