烟酰胺腺嘌呤二核苷酸（NAD+）作为一种调节新陈代谢的信号分子。
NAD+ as a signaling molecule modulating metabolism.
作者信息
Cantó C, Auwerx J
机构信息
Nestlé Institute of Health Sciences, CH-1015, Lausanne, Switzerland.
出版信息
Cold Spring Harb Symp Quant Biol. 2011;76:291-8. doi: 10.1101/sqb.2012.76.010439. Epub 2012 Feb 17.
Abstract
The ability of NAD(+) to act as a metabolic cofactor and as a rate-limiting cosubstrate for many enzymes, particularly the sirtuins, has led to the identification of a pivotal role of NAD(+) levels in the control of whole-body metabolic homeostasis. Bioavailability and compartmentalization of NAD(+) have become highly relevant issues that we need to understand in order to elucidate how NAD(+) acts both as a readout of the metabolic milieu and as an effector triggering appropriate cellular adaptations.
摘要
NAD⁺作为代谢辅助因子以及许多酶（特别是沉默调节蛋白）的限速共底物的能力，使得人们认识到NAD⁺水平在全身代谢稳态控制中起着关键作用。NAD⁺的生物利用度和区室化已成为高度相关的问题，为了阐明NAD⁺如何既作为代谢环境的一种指标，又作为触发适当细胞适应性的效应物，我们需要了解这些问题。
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