Rasmi Yousef, Seyyed-Mohammadzad Mir-Hossein
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
J Cardiovasc Dis Res. 2012 Jan;3(1):19-21. doi: 10.4103/0975-3583.91597.
Cardiac syndrome X (CSX) is a condition in which patients have the pain of angina despite normal coronary angiogram. Recently, Helicobacter pylori (H. pylori) bacteria has been associated with CSX. However, there is no obvious data about the frequency of its virulent strain (cytotoxine associated gene A: CagA) in patients with CSX. We surveyed the frequency of H. pylori and CagA antibodies in patients with cardiac syndrome X and healthy controls.
Plasma samples from 100 CSX patients (61 females and 39 males; mean age: 51.8 ± 12.3 years) and 100 healthy controls (61 females and 39 males; mean age: 48.9 ± 6.3 years) were tested for the presence of IgG antibody to H. pylori using enzyme linked immunosorbent assay (ELISA) method. Also, infected patients were determined by the presence of IgG antibody to CagA by ELISA method. Statistical analysis was carried out using chi-square test and independent samples T-test.
Ninety two percent (92/100) of patients were anti-H. pylori positive (anti-H. pylori+), while only 56.0% (56/100) of control group were anti-H. pylori+ (P<0.01). However, prevalence of anti-CagA positive (anti- CagA+) in H. pylori infected- CSX patients and control groups were 59.8% (55/92) and 60.7% (34/56), respectively (P>0.05).
Thus, due to the high frequency of anti-H. pylori in CSX patients, and the probable causative effect of chronic infection in vascular diseases, it is suggested that H. pylori has a probable role in the pathogenesis of CSX.
心脏X综合征（CSX）是一种患者尽管冠状动脉血管造影正常但仍有心绞痛症状的疾病。最近，幽门螺杆菌（H. pylori）与CSX有关。然而，关于CSX患者中其毒力菌株（细胞毒素相关基因A：CagA）的频率，尚无明确数据。我们调查了心脏X综合征患者和健康对照者中幽门螺杆菌及CagA抗体的频率。
采用酶联免疫吸附测定（ELISA）法检测100例CSX患者（61例女性和39例男性；平均年龄：51.8±12.3岁）和100例健康对照者（61例女性和39例男性；平均年龄：48.9±6.3岁）血浆样本中幽门螺杆菌IgG抗体的存在情况。此外，通过ELISA法检测CagA的IgG抗体来确定感染患者。使用卡方检验和独立样本T检验进行统计分析。
92%（92/100）的患者幽门螺杆菌抗体阳性（抗幽门螺杆菌+），而对照组中只有56.0%（56/100）抗幽门螺杆菌+（P<0.01）。然而，幽门螺杆菌感染的CSX患者和对照组中抗CagA阳性（抗CagA+）的患病率分别为59.8%（55/92）和60.7%（34/56）（P>0.05）。
因此，由于CSX患者中抗幽门螺杆菌的高频率，以及慢性感染在血管疾病中可能的致病作用，提示幽门螺杆菌在CSX的发病机制中可能起作用。
