Institute of Clinical Neuroanatomy, Goethe-University Frankfurt am Main, Germany.
Front Neuroanat. 2012 Feb 1;6:2. doi: 10.3389/fnana.2012.00002. eCollection 2012.
Much is known about the computation in individual neurons in the cortical column. Also, the selective connectivity between many cortical neuron types has been studied in great detail. However, due to the complexity of this microcircuitry its functional role within the cortical column remains a mystery. Some of the wiring behavior between neurons can be interpreted directly from their particular dendritic and axonal shapes. Here, I describe the dendritic density field (DDF) as one key element that remains to be better understood. I sketch an approach to relate DDFs in general to their underlying potential connectivity schemes. As an example, I show how the characteristic shape of a cortical pyramidal cell appears as a direct consequence of connecting inputs arranged in two separate parallel layers.
关于皮质柱中单个神经元的计算,人们已经了解很多。此外,许多皮质神经元类型之间的选择性连接也已经被详细研究过。然而,由于这个微电路的复杂性,它在皮质柱中的功能作用仍然是一个谜。神经元之间的一些布线行为可以直接从它们特定的树突和轴突形状来解释。在这里,我将树突密度场(DDF)描述为一个有待进一步理解的关键元素。我概述了一种将 DDF 与潜在的连接方案联系起来的方法。作为一个例子,我展示了如何将输入连接安排在两个单独的平行层中,作为直接结果,皮质金字塔细胞的特征形状出现。