Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden.
Psychol Med. 2012 Oct;42(10):2193-203. doi: 10.1017/S0033291712000244. Epub 2012 Feb 21.
Cognitive behaviour therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD) but access to CBT is limited. Internet-based CBT (ICBT) with therapist support is potentially a more accessible treatment. There are no randomized controlled trials testing ICBT for OCD. The aim of this study was to investigate the efficacy of ICBT for OCD in a randomized controlled trial.
Participants (n=101) diagnosed with OCD were randomized to either 10 weeks of ICBT or to an attention control condition, consisting of online supportive therapy. The primary outcome measure was the Yale-Brown Obsessive Compulsive Scale (YBOCS) administered by blinded assessors.
Both treatments lead to significant improvements in OCD symptoms, but ICBT resulted in larger improvements than the control condition on the YBOCS, with a significant between-group effect size (Cohen's d) of 1.12 (95% CI 0.69-1.53) at post-treatment. The proportion of participants showing clinically significant improvement was 60% (95% CI 46-72) in the ICBT group compared to 6% (95% CI 1-17) in the control condition. The results were sustained at follow-up.
ICBT is an efficacious treatment for OCD that could substantially increase access to CBT for OCD patients. Replication studies are warranted.
认知行为疗法(CBT)是治疗强迫症(OCD)的有效方法,但 CBT 的可及性有限。有治疗师支持的基于互联网的 CBT(ICBT)可能是一种更易获得的治疗方法。目前还没有针对 OCD 的 ICBT 的随机对照试验。本研究旨在通过随机对照试验来检验 ICBT 治疗 OCD 的疗效。
将被诊断为 OCD 的参与者(n=101)随机分配到 10 周的 ICBT 或注意力对照组,接受在线支持性治疗。主要结局指标是由盲法评估者进行的耶鲁-布朗强迫症量表(YBOCS)。
两种治疗方法均导致 OCD 症状显著改善,但 ICBT 在 YBOCS 上的改善程度大于对照组,治疗后组间效应量(Cohen's d)为 1.12(95% CI 0.69-1.53)。ICBT 组中显示临床显著改善的参与者比例为 60%(95% CI 46-72),而对照组为 6%(95% CI 1-17)。随访结果持续。
ICBT 是一种治疗 OCD 的有效方法,可以大大增加 OCD 患者接受 CBT 的机会。需要进行复制研究。