非甾体抗炎药或吸烟会增加幽门螺杆菌感染的易感性吗？
Do non-steroidal anti-inflammatory drugs or smoking predispose to Helicobacter pylori infection?
作者信息
Maxton D G, Srivastava E D, Whorwell P J, Jones D M
机构信息
Department of Medicine, University Hospital of South Manchester, West Didsbury, UK.
出版信息
Postgrad Med J. 1990 Sep;66(779):717-9. doi: 10.1136/pgmj.66.779.717.
Susceptibility to Helicobacter pylori infection is a poorly understood phenomenon. This study was undertaken to establish whether either smoking or chronic non-steroidal anti-inflammatory drug (NSAID) consumption might in some way predispose to H. pylori infection and hence lead to peptic ulceration. Serological evidence of H. pylori infection was assessed in 100 consecutive subjects receiving NSAIDs without any evidence of gastrointestinal upset and 100 matched controls. All subjects had a full assessment of their smoking habits. Sixty-three per cent of patients taking NSAIDs compared to 51% of controls had evidence of H. pylori infection (NS). Smoking habit also had no effect on H. pylori colonization. The ulcerogenic potential of NSAIDs and smoking does not appear to be mediated via a prediposition to H. pylori infection.
对幽门螺杆菌感染的易感性是一个尚未被充分理解的现象。本研究旨在确定吸烟或长期服用非甾体抗炎药（NSAID）是否会在某种程度上使人易患幽门螺杆菌感染，进而导致消化性溃疡。在100名连续接受NSAID治疗且无任何胃肠道不适证据的受试者以及100名匹配的对照者中，评估了幽门螺杆菌感染的血清学证据。所有受试者都对其吸烟习惯进行了全面评估。服用NSAID的患者中有63%有幽门螺杆菌感染的证据，而对照组为51%（无显著性差异）。吸烟习惯对幽门螺杆菌定植也没有影响。NSAID和吸烟的致溃疡潜力似乎不是通过使人易患幽门螺杆菌感染来介导的。
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