Child Nutrition Research Centre, Women's and Children's Hospital, Flinders Medical Centre, and Women's and Children's Health Research Institute, 72 King William Road, Adelaide, SA 5006, Australia.
Early Hum Dev. 2012 Aug;88(8):651-5. doi: 10.1016/j.earlhumdev.2012.01.013. Epub 2012 Feb 22.
Our aim was to examine the associations between maternal depression in the first 6 months postpartum, home environment and cognitive, language and motor development in infants at 18 months of age.
This article reports results from the control group (n=312 full term; n=48 preterm) of the prospective Docosahexaenoic acid (DHA) to Optimise Maternal Infant Outcome (DOMInO) Randomised Controlled Trial. Mothers in South Australia completed the Edinburgh Postnatal Depression Scale (EPDS) at 6 weeks and 6 months postpartum. Infant development was assessed when children were 18 months old with the Bayley Scales of Infant and Toddler Development Version III and mothers completed the Home Screening Questionnaire at this assessment.
There were no significant associations between maternal depression in the first 6 months postpartum and cognitive, language or motor development after controlling for infant prematurity, breastfeeding status and socio-economic level. Home environment remained a significant predictor of development after controlling for potential confounding variables. Using mediation models, we did not find an association between maternal depression and developmental outcome through home environment.
Maternal depression in the first 6 months postpartum was not associated with infant development at 18 months of age. Further studies should focus on women with chronic depression.
本研究旨在探讨产后 6 个月内产妇抑郁、家庭环境与婴儿 18 月龄时认知、语言和运动发育之间的关系。
本研究报告了前瞻性二十二碳六烯酸(DHA)优化母婴结局(DOMInO)随机对照试验对照组(n=312 例足月;n=48 例早产)的结果。南澳大利亚的母亲在产后 6 周和 6 个月时完成爱丁堡产后抑郁量表(EPDS)。当孩子 18 个月大时,使用贝利婴幼儿发展量表第三版评估婴儿发育,母亲在此评估时完成家庭筛查问卷。
在控制婴儿早产、母乳喂养状况和社会经济水平后,产后 6 个月内产妇抑郁与认知、语言或运动发育之间没有显著关联。在控制潜在混杂变量后,家庭环境仍然是发育的重要预测因素。使用中介模型,我们没有发现产妇抑郁与家庭环境通过家庭环境与发育结果之间的关联。
产后 6 个月内产妇抑郁与 18 月龄婴儿发育无关。进一步的研究应关注患有慢性抑郁症的女性。