Division of Oral Biology, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.
J Oral Microbiol. 2012;4. doi: 10.3402/jom.v4i0.10368. Epub 2012 Feb 21.
The deleterious and sometimes fatal outcomes of bacterial infectious diseases are the net result of the interactions between the pathogen and the host, and the genetically tractable fruit fly, Drosophila melanogaster, has emerged as a valuable tool for modeling the pathogen-host interactions of a wide variety of bacteria. These studies have revealed that there is a remarkable conservation of bacterial pathogenesis and host defence mechanisms between higher host organisms and Drosophila. This review presents an in-depth discussion of the Drosophila immune response, the Drosophila killing model, and the use of the model to examine bacterial-host interactions. The recent introduction of the Drosophila model into the oral microbiology field is discussed, specifically the use of the model to examine Porphyromonas gingivalis-host interactions, and finally the potential uses of this powerful model system to further elucidate oral bacterial-host interactions are addressed.
细菌感染性疾病的有害甚至致命后果是病原体和宿主相互作用的综合结果，而遗传上易于操作的黑腹果蝇已成为模拟各种细菌的病原体-宿主相互作用的有价值的工具。这些研究表明，在高等宿主生物和果蝇之间，细菌发病机制和宿主防御机制存在显著的保守性。本文深入探讨了果蝇的免疫反应、果蝇杀伤模型以及利用该模型研究细菌-宿主相互作用。讨论了最近将果蝇模型引入口腔微生物学领域，特别是利用该模型研究牙龈卟啉单胞菌-宿主相互作用，最后探讨了该强大模型系统在进一步阐明口腔细菌-宿主相互作用方面的潜在用途。
