Department of Psychiatry, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.
BMC Psychiatry. 2012 Feb 29;12:15. doi: 10.1186/1471-244X-12-15.
Cognitive processing in Bipolar Disorder is characterized by a number of attentional abnormalities. Mindfulness Based Cognitive Therapy combines mindfulness meditation, a form of attentional training, along with aspects of cognitive therapy, and may improve attentional dysfunction in bipolar disorder patients.
12 euthymic BD patients and 9 control participants underwent record of electroencephalography (EEG, band frequency analysis) during resting states (eyes open, eyes closed) and during the completion of a continuous performance task (A-X version, EEG event-related potential (ERP) wave component analysis). The individuals with BD completed an 8-week MBCT intervention and record of EEG was repeated.
(1) Brain activity, individuals with BD showed significantly decreased theta band power, increased beta band power, and decreased theta/beta ratios during the resting state, eyes closed, for frontal and cingulate cortices. Post MBCT intervention improvement over the right frontal cortex was seen in the individuals with BD, as beta band power decreased. (2) Brain activation, individuals with BD showed a significant P300-like wave form over the frontal cortex during the cue. Post MBCT intervention the P300-like waveform was significantly attenuated over the frontal cortex.
Individuals with BD show decreased attentional readiness and activation of non-relevant information processing during attentional processes. These data are the first that show, MBCT in BD improved attentional readiness, and attenuated activation of non-relevant information processing during attentional processes.
双相情感障碍的认知加工表现出多种注意力异常。正念认知疗法结合正念冥想，一种注意力训练形式，以及认知疗法的各个方面，可能改善双相情感障碍患者的注意力功能障碍。
12 名缓解期双相情感障碍患者和 9 名对照参与者在静息状态（睁眼、闭眼）和连续性能任务（A-X 版本，脑电图事件相关电位（ERP）波成分分析）期间记录脑电图（EEG，频带频率分析）。双相情感障碍患者完成了 8 周的正念认知疗法干预，重复记录脑电图。
（1）大脑活动，双相情感障碍患者在静息状态、闭眼时，额叶和扣带回皮质的θ波段功率降低，β波段功率增加，θ/β 比值降低。MBCT 干预后，双相情感障碍患者右额叶的β波段功率降低，提示其大脑活动改善。（2）大脑激活，双相情感障碍患者在提示时，额叶出现明显的 P300 样波。MBCT 干预后，额叶的 P300 样波明显减弱。
双相情感障碍患者在注意力过程中表现出注意力准备和无关信息处理的激活降低。这些数据首次表明，正念认知疗法在双相情感障碍中改善了注意力准备，并减轻了注意力过程中无关信息处理的激活。
