Department of Pain Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Neuromodulation. 2012 Mar-Apr;15(2):151-4; discussion 154. doi: 10.1111/j.1525-1403.2012.00438.x. Epub 2012 Feb 29.
We examined the efficacy of temporary spinal cord stimulation involving the insertion of only a needle and quadripolar lead into the epidural space and applied using an extracorporeal stimulation generator for a few weeks of early postherpetic neuralgia from one to six months of its onset.
Temporary spinal cord stimulation was applied in 33 patients with postherpetic neuralgia and in whom epidural block was effective. Temporary spinal cord stimulation was applied over seven days, and analgesic effects was evaluated based on visual analog scale (VAS) values before and after one, three, and six months following treatment. An analgesic effect was defined as a decrease of over 50% in the VAS value compared with before treatment.
VAS values decreased significantly from 68.1 mm (standard deviation [SD]± 15.2) before treatment to 37.5 mm (SD ± 20.4) after one month, to 38.0 mm (SD ± 18.7) after three months, and to 35.0 mm (SD ± 21.3) after six months. In 21/33 (63.6%) cases, an analgesic effect, defined as a decrease in the VAS value of greater than 50%, was observed one month after treatment, in 20/33 (60.6%) cases such an effect was observed three months after treatment, and in 21/33 (63.6%) cases the effect was still observed six months after treatment.
Temporary spinal cord stimulation is an effective analgesic method for early postherpetic neuralgia from one to six months of its onset.
我们研究了仅通过插入硬膜外腔的一根针和四极导联,并使用体外刺激发生器在带状疱疹后神经痛发作后 1 至 6 个月的早期应用数周,评估临时脊髓刺激的疗效。
在 33 例带状疱疹后神经痛且硬膜外阻滞有效的患者中应用临时脊髓刺激。临时脊髓刺激应用 7 天,根据治疗后 1、3 和 6 个月的视觉模拟量表(VAS)值评估镇痛效果。镇痛效果定义为与治疗前相比 VAS 值下降超过 50%。
VAS 值从治疗前的 68.1mm(标准差[SD]±15.2)显著下降至治疗后 1 个月的 37.5mm(SD ±20.4),3 个月时为 38.0mm(SD ±18.7),6 个月时为 35.0mm(SD ±21.3)。在 21/33(63.6%)例患者中,治疗后 1 个月观察到镇痛效果,定义为 VAS 值下降超过 50%,在 20/33(60.6%)例患者中观察到治疗后 3 个月的镇痛效果,在 21/33(63.6%)例患者中观察到治疗后 6 个月的镇痛效果。
临时脊髓刺激是治疗带状疱疹后神经痛发作后 1 至 6 个月的有效镇痛方法。