金属纳米粒子介导的光动力治疗的最新进展。
Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy.
机构信息
College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA.
出版信息
Molecules. 2018 Jul 12;23(7):1704. doi: 10.3390/molecules23071704.
Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently available photosensitizers (PSs). Water solubility of PSs is crucial for designing pharmaceutical formulation and administration routes. Wavelength of light source at visible range normally has therapeutic depth less than 1 mm. In this review, focus is on the recent research progress of metal-based nanoparticles being applied in PDT. The potential toxicity of these nanoscales and future directions are further discussed.
光动力疗法（PDT）能够通过结合光、氧和光敏剂（PSs）来非侵入性地治疗和诊断各种癌症和非恶性疾病。然而，目前可用的光敏剂（PSs）的水溶性差和光穿透深度有限，限制了 PDT 的应用。PSs 的水溶性对于设计药物制剂和给药途径至关重要。可见光范围内光源的波长通常具有小于 1 毫米的治疗深度。本综述重点介绍了金属基纳米粒子在 PDT 中的应用的最新研究进展。进一步讨论了这些纳米级的潜在毒性和未来方向。
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