Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Kumamoto, 860-0082, Japan.
J Nat Med. 2012 Oct;66(4):658-63. doi: 10.1007/s11418-012-0637-z. Epub 2012 Mar 3.
A new characteristic steroidal glycoside possessing a hydroxyl group at C-23, inunigroside A (1), was isolated from the withered berries of Solanum nigrum L. On the basis of spectroscopic analysis, the structure of 1 was characterized as (5α,22S,23S,25R)-3β,23-dihydroxyspirostane 3-O-β-lycotetraoside. Next, a major steroidal sapogenol, (22R, 25S)-3β,15α-dihydroxy-spirost-5-ene (3), was obtained from the acid hydrolysate of the methanolic extract of the aerial parts of Solanum jasminoides L. A new bisdesmoside, 3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl (22R,25S)-3β,15α-dihydroxyspirost-5-ene 15-O-α-L-rhamnopyranoside (4), named jasminoside A, was isolated from the methanolic extract of S. jasminoides.
从龙葵的干枯浆果中分离得到一种新的甾体糖苷，命名为茵芋苷 A（1），它在 C-23 位具有一个羟基。基于光谱分析，确定 1 的结构为（5α,22S,23S,25R）-3β,23-二羟基螺甾烷 3-O-β-黎芦醇四糖苷。接着，从龙葵地上部分甲醇提取物的酸水解产物中得到一种主要的甾体皂甙，（22R,25S）-3β,15α-二羟基螺甾-5-烯（3）。从龙葵甲醇提取物中分离得到一种新的双糖苷，3-O-β-D-吡喃葡萄糖基-（1→4）-β-D-吡喃葡萄糖基-（1→4）-β-D-吡喃葡萄糖基（22R,25S）-3β,15α-二羟基螺甾-5-烯 15-O-α-L-鼠李吡喃糖苷（4），命名为茉莉苷 A。
