Crocetti Emanuele, Buzzoni Carlotta, Chiarugi Alessandra, Nardini Paolo, Pimpinelli Nicola
Clinical and Descriptive Epidemiology Unit, Institute for Cancer Study and Prevention (ISPO), Via delle Oblate 2, 50141 Florence, Italy.
ISRN Oncol. 2012;2012:864680. doi: 10.5402/2012/864680. Epub 2012 Jan 16.
Objective. Evaluate the ecological relationship between skin melanoma epidemiology and latitude in Italy. Methods. We used data from the Italian network of cancer registries (Airtum). In a Poisson model, we evaluated the effect on incidence, mortality, and survival of latitude, adjusting for some demographic, social, phenotypic, and behavioural variables. Results. Incidence increased in Italy by 17% for each degree of increase in latitude. The effect of latitude was statistically significantly present also adjusting for other variables (incidence rate ratio = 1.08). The effect of latitude on increasing mortality (mortality rate ratio = 1.27) and improving survival (relative excess risk of death = 0.93) was no longer present in the multivariate model. Conclusion. Melanoma incidence, mortality, and survival vary in Italy according to latitude. After adjustment for several confounders, incidence still grows with growing latitude. Presumably, latitude expresses other variables that might be related to individual susceptibility and/or local care.
目的。评估意大利皮肤黑色素瘤流行病学与纬度之间的生态关系。方法。我们使用了意大利癌症登记网络（Airtum）的数据。在泊松模型中，我们评估了纬度对发病率、死亡率和生存率的影响，并对一些人口统计学、社会、表型和行为变量进行了调整。结果。在意大利，纬度每升高一度，发病率增加17%。在对其他变量进行调整后，纬度的影响在统计学上仍然显著（发病率比值比 = 1.08）。在多变量模型中，纬度对死亡率增加（死亡率比值比 = 1.27）和生存率提高（死亡相对超额风险 = 0.93）的影响不再存在。结论。在意大利，黑色素瘤的发病率、死亡率和生存率随纬度而变化。在对几个混杂因素进行调整后，发病率仍随纬度升高而增长。据推测，纬度反映了其他可能与个体易感性和/或当地医疗护理相关的变量。
