Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Exp Cell Res. 2012 Jul 15;318(12):1456-60. doi: 10.1016/j.yexcr.2012.02.015. Epub 2012 Feb 25.
The ends of eukaryotic chromosomes are called telomeres. This article provides a short history of telomere and telomerase research starting with the pioneering work of Muller and McClintock through the molecular era of telomere biology. These studies culminated in the 2009 Nobel Prize in Medicine. Critical findings that moved the field forward and that suggest directions for future research are emphasized.
真核生物染色体的末端称为端粒。本文简要回顾了端粒和端粒酶的研究历史，从 Muller 和 McClintock 的开创性工作开始，一直到端粒生物学的分子时代。这些研究最终促成了 2009 年诺贝尔生理学或医学奖的诞生。本文强调了推动该领域前进的关键发现，并为未来的研究指明了方向。
