Department of Occupational Therapy, University of Illinois at Chicago, 1919 West Taylor Street, MC 811, Chicago, IL 60612-7250, USA.
Am J Occup Ther. 2012 Mar-Apr;66(2):187-97. doi: 10.5014/ajot.2012.003160.
We determined whether age, gender, work status, or impairment moderated fatigue management program outcomes for people with multiple sclerosis (MS).
We conducted a secondary analysis of longitudinal data from a randomized controlled trial using mixed-effects models (N = 181) and examined outcomes of fatigue impact, mental health, physical health, and self-efficacy. Measures were collected before and immediately after intervention and at 6 wk, 3 mo, and 6 mo postintervention.
Younger participants experienced greater reductions in fatigue impact and greater improvements in self-efficacy over time than did older participants, but we found no age differences in physical or mental health. Participants with less impairment experienced greater mental health gains and were more likely to retain these gains over time than were participants with greater impairment. Although women experienced greater fatigue impact benefits, men experienced greater mental health benefits. Work status did not moderate outcomes.
Fatigue management program outcomes for people with MS are moderated by age, gender, and impairment.
我们旨在确定年龄、性别、工作状态或失能是否会影响多发性硬化症（MS）患者的疲劳管理计划结果。
我们使用混合效应模型（N=181）对一项随机对照试验的纵向数据进行了二次分析，并检查了疲劳影响、心理健康、身体健康和自我效能的结果。在干预前、干预后即刻以及干预后 6 周、3 个月和 6 个月时收集了这些指标。
与年龄较大的参与者相比，年轻参与者在疲劳影响方面的减轻程度更大，自我效能的提高程度也更大，但在身体或心理健康方面我们没有发现年龄差异。与失能程度较高的参与者相比，失能程度较低的参与者在心理健康方面的改善更大，并且随着时间的推移更有可能保持这些改善。尽管女性在疲劳影响方面获益更大，但男性在心理健康方面获益更大。工作状态未对结果产生调节作用。
多发性硬化症患者的疲劳管理计划结果受到年龄、性别和失能程度的调节。
