Department of Radiation Oncology, Mount Sinai Medical Center Box 1236, New York 10029, USA.
Anticancer Res. 2012 Mar;32(3):1113-5.
Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor, accounting for 52% of all primary brain tumor cases and 20% of all intracranial tumors. Recently, evidence for a viral cause has been postulated, possibly cytomegalovirus (CMV). In one report, 80% of patients with newly diagnosed glioblastoma multiforme had detectable cytomegalovirus DNA in their peripheral blood, while sero-positive normal donors and other surgical patients did not exhibit detectable virus. However, another study reported that five glioblastoma patients showed no circulating CMV detected either with RT-PCR or blood culture.
We utilized Cytomegalovirus Seroprevalence in the United States data from the National Health and Nutrition Examination Surveys, 1988-2004. Glioblastoma Incidence Rates 2004-2008 by race and gender are from Cancer of the Brain and Other Nervous System - SEER Stat Fact Sheets (http://seer.cancer.gov/statfacts/html/brain.html). Statistical significance was determined from published 95% confidence intervals.
CMV seroprevalence rates are not consistently related to glioblastoma incidence rates. CMV seroprevalence is significantly lower in whites than in blacks or Hispanics (Mexican Americans), while glioblastoma incidence is higher. However, both CMV seroprevalence and glioblastoma incidence are higher in Hispanics than in blacks. CMV seroprevalence rates are significantly higher in women, 55.5% (53.3-57.7, mean ± 95% CI) than men, 45.2% (42.4-48.0), although glioblastoma is more common in men.
A possible CMV-glioblastoma association cannot be readily substantiated with CMV seropositivity rates.
多形性胶质母细胞瘤是最常见和最具侵袭性的原发性脑肿瘤，占所有原发性脑肿瘤病例的 52%，占所有颅内肿瘤的 20%。最近，有人提出病毒可能是病因，可能是巨细胞病毒（CMV）。在一份报告中，80%的新诊断为多形性胶质母细胞瘤的患者在外周血中可检测到巨细胞病毒 DNA，而血清阳性的正常供体和其他手术患者则未检测到病毒。然而，另一项研究报告称，五名胶质母细胞瘤患者无论是通过 RT-PCR 还是血液培养均未检测到循环 CMV。
我们利用了美国国家健康和营养检查调查（National Health and Nutrition Examination Surveys）1988-2004 年期间的巨细胞病毒血清阳性率数据。种族和性别 2004-2008 年的胶质母细胞瘤发病率数据来自脑癌和其他神经系统癌症 - SEER 统计事实表（http://seer.cancer.gov/statfacts/html/brain.html）。统计显著性是根据已发表的 95%置信区间确定的。
CMV 血清阳性率与胶质母细胞瘤发病率并不一致相关。白人的 CMV 血清阳性率明显低于黑人和西班牙裔（墨西哥裔美国人），而胶质母细胞瘤的发病率更高。然而，西班牙裔的 CMV 血清阳性率和胶质母细胞瘤的发病率均高于黑人。CMV 血清阳性率在女性中明显更高，为 55.5%（53.3-57.7，平均值±95%CI），而男性为 45.2%（42.4-48.0），尽管胶质母细胞瘤在男性中更为常见。
CMV 血清阳性率不能轻易证实 CMV 与胶质母细胞瘤之间可能存在关联。
